dc.contributor.author |
Kovács, Dávid |
|
dc.contributor.author |
Kovács, Péter |
|
dc.contributor.author |
Eszlari, Nóra |
|
dc.contributor.author |
Gonda, Xénia |
|
dc.contributor.author |
Juhász, Gabriella |
|
dc.date.accessioned |
2016-08-24T06:37:25Z |
|
dc.date.available |
2016-08-24T06:37:25Z |
|
dc.date.issued |
2016 |
|
dc.identifier.citation |
pagination=97-103;
journalVolume=29;
journalTitle=CURRENT OPINION IN PHARMACOLOGY; |
|
dc.identifier.uri |
http://repo.lib.semmelweis.hu//handle/123456789/3653 |
|
dc.identifier.uri |
doi:10.1016/j.coph.2016.06.008 |
|
dc.description.abstract |
Immunotherapies revolutionised the treatment of several disorders but show specific side-effect profiles which frequently involve psychological symptoms. Long term interferon-alpha (IFN-alpha) therapy can cause wide-ranging psychiatric side-effects from fatigue, insomnia, anxiety to full-blown depression. This treatment-emergent depression shares several symptoms with major depressive disorder (MDD) with a predominance of somatic/neurovegetative symptoms, and can be treated with antidepressants. However, this experience directed research to inflammatory mechanisms in MDD. MDD has been confirmed as a heterogeneous disorder with a subgroup of patients suffering from low-grade chronic inflammation and frequently resistant to traditional antidepressant treatment. Thus future research should develop strategies to identify those MDD patients who could benefit from drugs acting through inflammatory pathways. |
|
dc.relation.ispartof |
urn:issn:1471-4892 |
|
dc.title |
Psychological side effects of immune therapies: symptoms and pathomechanism |
|
dc.type |
Journal Article |
|
dc.date.updated |
2016-08-22T08:40:48Z |
|
dc.language.rfc3066 |
en |
|
dc.identifier.mtmt |
3102163 |
|
dc.identifier.pubmed |
27456240 |
|
dc.contributor.department |
SE/GYTK/Gyógyszerhatástani Intézet |
|
dc.contributor.department |
SE/GYTK/GYHATAS/MTA-SE Neuropszichofarmakológiai és Neurokémiai Kutatócsoport |
|
dc.contributor.department |
SE/GYTK/GYHATAS/MTA-SE-NAP B Genetikai Agyi Képalkotó Migrén Kutató Csoport |
|
dc.contributor.institution |
Semmelweis Egyetem |
|