HPLC analysis in drug level monitoring of K027

dc.contributor.author	Nurulain S
dc.contributor.author	Kalász Huba
dc.contributor.author	Szegi Péter
dc.contributor.author	Kuca K
dc.contributor.author	Adem A
dc.contributor.author	FARZAD HASHEMI
dc.contributor.author	Tekes Kornélia
dc.date.accessioned	2014-09-04T21:15:35Z
dc.date.available	2014-09-04T21:15:35Z
dc.date.issued	2013
dc.identifier	84885923496
dc.identifier.citation	pagination=703-710; journalVolume=25; journalIssueNumber=4; journalTitle=ACTA CHROMATOGRAPHICA;
dc.identifier.uri	http://repo.lib.semmelweis.hu//handle/123456789/386
dc.identifier.uri	doi:10.1556/AChrom.25.2013.4.8
dc.description.abstract	HPLC monitoring of pharmacokinetics was done in two body compartments of rats following intramuscular treatments with three different doses of K027, a bispyridinium mono-aldoxime type of antidotes to organoposphate intoxicated subjects. Reversed-phase HPLC separation with electrochemical detections was done to monitor the onset, the maximum level, and offset in K027 concentration. Serum level of K027 showed a fast onset, independently from the doses of K027. Drug level in brain was showing an essentially delayed kinetics.
dc.relation.ispartof	urn:issn:1233-2356
dc.title	HPLC analysis in drug level monitoring of K027
dc.type	Journal Article
dc.date.updated	2014-09-04T13:50:04Z
dc.language.rfc3066	en
dc.identifier.mtmt	2484113
dc.identifier.wos	000325291400008
dc.contributor.department	SE/GYTK/Gyógyszerhatástani Intézet
dc.contributor.institution	Semmelweis Egyetem