Integrated (epi)-Genomic Analyses Identify Subgroup-Specific Therapeutic Targets  in CNS Rhabdoid Tumors

dc.contributor.author	Torchia, Jonathon
dc.contributor.author	Golbourn, Brian
dc.contributor.author	Feng, Shengrui
dc.contributor.author	Ho, King Ching
dc.contributor.author	Sin-Chan, Patrick
dc.contributor.author	Alexandre, Vasiljevic
dc.contributor.author	Joseph, D Norman
dc.contributor.author	Paul, Guilhamon
dc.contributor.author	Livia, Garzia
dc.contributor.author	Natalia, R Agamez
dc.contributor.author	Mei, Lu
dc.contributor.author	Tiffany, S Chan
dc.contributor.author	Daniel, Picard
dc.contributor.author	Pasqualino, de Antonellis
dc.contributor.author	Dong-Anh, Khuong-Quang
dc.contributor.author	Aline, C Planello
dc.contributor.author	Constanze, Zeller
dc.contributor.author	Dalia, Barsyte-Lovejoy
dc.contributor.author	Lucie, Lafay-Cousin
dc.contributor.author	Louis, Letourneau
dc.contributor.author	Mathieu, Bourgey
dc.contributor.author	Man, Yu
dc.contributor.author	Deena, MA Gendoo
dc.contributor.author	Misko, Dzamba
dc.contributor.author	Mark, Barszczyk
dc.contributor.author	Tiago, Medina
dc.contributor.author	Alexandra, N Riemenschneider
dc.contributor.author	A Sorana, Morrissy
dc.contributor.author	Young-Shin, Ra
dc.contributor.author	Vijay, Ramaswamy
dc.contributor.author	Marc, Remke
dc.contributor.author	Christopher, P Dunham
dc.contributor.author	Stephen, Yip
dc.contributor.author	Ho-Keung, Ng
dc.contributor.author	Jian-Qiang, Lu
dc.contributor.author	Vivek, Mehta
dc.contributor.author	Vivek, Mehta
dc.contributor.author	Steffen, Albrecht
dc.contributor.author	Jose, Pimentel
dc.contributor.author	Jennifer, A Chan
dc.contributor.author	Gino, R Somers
dc.contributor.author	Claudia, C Faria
dc.contributor.author	Lucia, Roque
dc.contributor.author	Maryam, Fouladi
dc.contributor.author	Lindsey, M Hoffman
dc.contributor.author	Andrew, S Moore
dc.contributor.author	Yin, Wang
dc.contributor.author	Seung, Ah Choi
dc.contributor.author	Jordan, R Hansford
dc.contributor.author	Daniel, Catchpoole
dc.contributor.author	Diane, K Birks
dc.contributor.author	Nicholas, K Foreman
dc.contributor.author	Doug, Strother
dc.contributor.author	Álmos, Klekner
dc.contributor.author	László, Bognár
dc.contributor.author	Garami, Miklós
dc.contributor.author	Hauser, Péter
dc.contributor.author	Hortobágyi, Tibor
dc.contributor.author	Beverly, Wilson
dc.contributor.author	Juliette, Hukin
dc.contributor.author	Anne-Sophie, Carret
dc.contributor.author	Timothy, E Van Meter
dc.contributor.author	Eugene, I Hwang
dc.contributor.author	Amar, Gajjar
dc.contributor.author	Shih-Hwa, Chiou
dc.contributor.author	Hideo, Nakamura
dc.contributor.author	Helen, Toledano
dc.contributor.author	Iris, Fried
dc.contributor.author	Daniel, Fults
dc.contributor.author	Takafumi, Wataya
dc.contributor.author	Chris, Fryer
dc.contributor.author	David, D Eisenstat
dc.contributor.author	Katrin, Scheinemann
dc.contributor.author	Adam, J Fleming
dc.contributor.author	Donna, L Johnston
dc.contributor.author	Jean, Michaud
dc.contributor.author	Shayna, Zelcer
dc.contributor.author	Robert, Hammond
dc.contributor.author	Samina, Afzal
dc.contributor.author	David, A Ramsay
dc.contributor.author	Nongnuch, Sirachainan
dc.contributor.author	Suradej, Hongeng
dc.contributor.author	Noppadol, Larbcharoensub
dc.contributor.author	Richard, G Grundy
dc.contributor.author	Rishi, R Lulla
dc.contributor.author	Jason, R Fangusaro
dc.contributor.author	Harriet, Druker
dc.contributor.author	Ute, Bartels
dc.contributor.author	Ronald, Grant
dc.contributor.author	David, Malkin
dc.contributor.author	C Jane, McGlade
dc.contributor.author	Theodore, Nicolaides
dc.contributor.author	Tarik, Tihan
dc.contributor.author	Joanna, Phillips
dc.contributor.author	Jacek, Majewski
dc.contributor.author	Alexandre, Montpetit
dc.contributor.author	Guillaume, Bourque
dc.contributor.author	Gary, D Bader
dc.contributor.author	Alyssa, T Reddy
dc.contributor.author	G Yancey, Gillespie
dc.contributor.author	Monika, Warmuth-Metz
dc.contributor.author	Stefan, Rutkowski
dc.contributor.author	Uri, Tabori
dc.contributor.author	Mathieu, Lupien
dc.contributor.author	Michael, Brudno
dc.contributor.author	Ulrich, Sch€uller
dc.contributor.author	Torsten, Pietsch
dc.contributor.author	Alexander, R Judkins
dc.contributor.author	Cynthia, E Hawkins
dc.contributor.author	Eric, Bouffet
dc.contributor.author	Seung-Ki, Kim
dc.contributor.author	Peter, B Dirks
dc.contributor.author	Michael, D Taylor
dc.contributor.author	Anat, Erdreich-Epstein
dc.contributor.author	Cheryl, H Arrowsmith
dc.contributor.author	Daniel, D De Carvalho
dc.contributor.author	James, T Rutka
dc.contributor.author	Nada, Jabado
dc.contributor.author	Annie, Huang
dc.date.accessioned	2017-02-08T12:24:28Z
dc.date.available	2017-02-08T12:24:28Z
dc.date.issued	2016
dc.identifier.citation	pagination=891-908; journalVolume=30; journalIssueNumber=6; journalTitle=CANCER CELL;
dc.identifier.uri	http://repo.lib.semmelweis.hu//handle/123456789/4053
dc.identifier.uri	doi:10.1016/j.ccell.2016.11.003
dc.description.abstract	We recently reported that atypical teratoid rhabdoid tumors (ATRTs) comprise at least two transcriptional subtypes with different clinical outcomes; however, the mechanisms underlying therapeutic heterogeneity remained unclear. In this study, we analyzed 191 primary ATRTs and 10 ATRT cell lines to define the genomic and epigenomic landscape of ATRTs and identify subgroup-specific therapeutic targets. We found ATRTs segregated into three epigenetic subgroups with distinct genomic profiles, SMARCB1 genotypes, and chromatin landscape that correlated with differential cellular responses to a panel of signaling and epigenetic inhibitors. Significantly, we discovered that differential methylation of a PDGFRB-associated enhancer confers specific sensitivity of group 2 ATRT cells to dasatinib and nilotinib, and suggest that these are promising therapies for this highly lethal ATRT subtype.
dc.relation.ispartof	urn:issn:1535-6108
dc.title	Integrated (epi)-Genomic Analyses Identify Subgroup-Specific Therapeutic Targets in CNS Rhabdoid Tumors
dc.type	Journal Article
dc.date.updated	2017-01-30T10:48:46Z
dc.language.rfc3066	en
dc.identifier.mtmt	3160773
dc.identifier.pubmed	27960086
dc.contributor.department	SE/AOK/K/II. Sz. Gyermekgyógyászati Klinika
dc.contributor.institution	Semmelweis Egyetem