Show simple item record Tomsits, Erika Pataki, Margit Tölgyesi, Andrea Fekete, György Rischák, Katalin Szollár, Lajos 2017-03-29T14:21:42Z 2017-03-29T14:21:42Z 2010
dc.identifier 78449249520
dc.identifier.citation pagination=514-521; journalVolume=51; journalIssueNumber=4; journalTitle=JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION;
dc.identifier.uri doi:10.1097/MPG.0b013e3181de210c
dc.description.abstract OBJECTIVES: Safety, tolerability, and efficacy of a novel lipid emulsion containing a mixture of soybean oil, medium-chain triglycerides, olive oil, and fish oil (SMOFlipid 20%) with reduced n-6 fatty acids (FA), increased monounsaturated and n-3 FA, and enriched in vitamin E were evaluated in premature infants compared with a soybean oil-based emulsion. PATIENTS AND METHODS: Sixty (30/30) premature neonates (age 3-7 days, gestational age </= 34 weeks, birth weights 1000-2500 g) received parenteral nutrition (PN) with either SMOFlipid 20% (study group) or a conventional lipid emulsion (Intralipid 20%, control group) for a minimum of 7 up to 14 days. Lipid supply started at 0.5 g . kg body weight(-1) . day(-1) on day 1 and increased stepwise (by 0.5 g) up to 2 g . kg body weight(-1) . day(-1) on days 4 to 14. Safety and efficacy parameters were assessed on days 0, 8, and 15 if PN was continued. RESULTS: Adverse events, serum triglycerides, vital signs, local tolerance, and clinical laboratory did not show noticeable group differences, confirming the safety of study treatment. At study end, gamma-glutamyl transferase was lower in the study versus the control group (107.8 +/- 81.7 vs 188.8 +/- 176.7 IU/L, P < 0.05). The relative increase in body weight (day 8 vs baseline) was 5.0% +/- 6.5% versus 5.1% +/- 6.6% (study vs control, not significant). In the study group, an increase in n-3 FA in red blood cell phospholipids and n-3:n-6 FA ratio was observed. Plasma alpha-tocopherol (study vs control) was increased versus baseline on day 8 (26.35 +/- 10.03 vs 3.67 +/- 8.06 mumol/L, P < 0.05) and at study termination (26.97 +/- 18.32 vs 8.73 +/- 11.41 mumol/L, P < 0.05). CONCLUSIONS: Parenteral infusion of SMOFlipid was safe and well tolerated and showed a potential beneficial influence on cholestasis, n-3 FA, and vitamin E status in premature infants requiring PN.
dc.relation.ispartof urn:issn:0277-2116
dc.title Safety and efficacy of a lipid emulsion containing a mixture of soybean oil, medium-chain triglycerides, olive oil, and fish oil
dc.type Journal Article 2017-03-29T10:19:18Z
dc.language.rfc3066 en
dc.identifier.mtmt 1627242
dc.identifier.wos 000282123600024
dc.identifier.pubmed 20531018
dc.contributor.department SE/AOK/K/II. Sz. Gyermekgyógyászati Klinika
dc.contributor.department SE/AOK/I/Kórélettani Intézet
dc.contributor.institution Semmelweis Egyetem

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