Kivonat:
We examined the association of functional ABCB1 (MDR1) and ABCG2 (BCRP)
polymorphisms with acute side effects of chemotherapy. Analyses were performed on
clinical data from 138 patients treated with the ALL-BFM-95 protocol implying
several substrates of these transporters. ABCB1 3435T>C, 2677G>T/A 1236C>T and
ABCG2 421C>A genotypes were determined. A higher proportion of ABCB1 3435TT
patients suffered excessive infectious complications than those harbouring at
least one C allele (OR=2.5, p=0.03) during the whole half-year-long intensive
phase of chemotherapy. Weaker associations were calculated when ABCB1
1236T-2677T-3435T haplotype homozygotes were tested against the remaining part of
the population (OR=2.3, p=0.09). During the reinduction phase of therapy, the
occurrence of severe leukocytopenia was similar among ABCB1 genotype groups. The
frequency of any toxicities were not shown to differ according to the ABCG2
421C>A genotype. Our data suggest that the ABCB1 3435T>C genotype is associated
with the infectious complications of the applied chemotherapy regimen.
