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dc.contributor.author Juhász, Gabriella
dc.contributor.author Csépány, Éva
dc.contributor.author Magyar, Máté
dc.contributor.author Édes, Andrea Edit
dc.contributor.author Eszlári, Nóra
dc.contributor.author Hullám, Gábor István
dc.contributor.author Antal P
dc.contributor.author Kökönyei, Gyöngyi
dc.contributor.author Anderson IM
dc.contributor.author Deakin JF
dc.contributor.author Bagdy, György
dc.date.accessioned 2017-06-07T07:38:40Z
dc.date.available 2017-06-07T07:38:40Z
dc.date.issued 2017
dc.identifier 85005808170
dc.identifier.citation pagination=384-393; journalVolume=16; journalIssueNumber=3; journalTitle=GENES BRAIN AND BEHAVIOR;
dc.identifier.uri http://repo.lib.semmelweis.hu//handle/123456789/4294
dc.identifier.uri doi:10.1111/gbb.12352
dc.description.abstract One of the main effects of the endocannabinoid system in the brain is stress adaptation with presynaptic endocannabinoid receptor 1 (CB1 receptors) playing a major role. In the present study, we investigated whether the effect of the CB1 receptor coding CNR1 gene on migraine and its symptoms is conditional on life stress. In a cross-sectional European population (n = 2426), recruited from Manchester and Budapest, we used the ID-Migraine questionnaire for migraine screening, the Life Threatening Experiences questionnaire to measure recent negative life events (RLE), and covered the CNR1 gene with 11 SNPs. The main genetic effects and the CNR1 x RLE interaction with age and sex as covariates were tested. None of the SNPs showed main genetic effects on possible migraine or its symptoms, but 5 SNPs showed nominally significant interaction with RLE on headache with nausea using logistic regression models. The effect of rs806366 remained significant after correction for multiple testing and replicated in the subpopulations. This effect was independent from depression- and anxiety-related phenotypes. In addition, a Bayesian systems-based analysis demonstrated that in the development of headache with nausea all SNPs were more relevant with higher a posteriori probability in those who experienced recent life stress. In summary, the CNR1 gene in interaction with life stress increased the risk of headache with nausea suggesting a specific pathological mechanism to develop migraine, and indicating that a subgroup of migraine patients, who suffer from life stress triggered migraine with frequent nausea, may benefit from therapies that increase the endocannabinoid tone.
dc.relation.ispartof urn:issn:1601-1848
dc.title Variants in the CNR1 gene predispose to headache with nausea in the presence of life stress.
dc.type Journal Article
dc.date.updated 2017-04-07T10:39:58Z
dc.language.rfc3066 en
dc.identifier.mtmt 3130639
dc.identifier.pubmed 27762084
dc.contributor.department SE/GYTK/Gyógyszerhatástani Intézet
dc.contributor.department SE/GYTK/GYHATAS/MTA-SE Neuropszichofarmakológiai és Neurokémiai Kutatócsoport
dc.contributor.department SE/AOK/K/Neurológiai Klinika
dc.contributor.department SE/GYTK/GYHATAS/NAP-A-SE Új Antidepresszív Gyógyszercélpont Kutatócsoport
dc.contributor.department SE/GYTK/GYHATAS/MTA-SE-NAP B Genetikai Agyi Képalkotó Migrén Kutató Csoport
dc.contributor.institution Semmelweis Egyetem


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