dc.contributor.author |
Golovics, Petra Anna |
|
dc.contributor.author |
Lakatos, László |
|
dc.contributor.author |
Nagy A |
|
dc.contributor.author |
Pandur T |
|
dc.contributor.author |
Szita I |
|
dc.contributor.author |
Balogh M |
|
dc.contributor.author |
Molnar C |
|
dc.contributor.author |
Komaromi E |
|
dc.contributor.author |
Lovász, Barbara Dorottya |
|
dc.contributor.author |
Mandel M |
|
dc.contributor.author |
Veres, Gábor |
|
dc.contributor.author |
Kiss, Lajos Sándor |
|
dc.contributor.author |
Végh, Zsuzsanna |
|
dc.contributor.author |
Lakatos, Péter László |
|
dc.date.accessioned |
2014-12-07T17:39:25Z |
|
dc.date.available |
2014-12-07T17:39:25Z |
|
dc.date.issued |
2013 |
|
dc.identifier |
84888095716 |
|
dc.identifier.citation |
pagination=7701-7710;
journalVolume=19;
journalIssueNumber=43;
journalTitle=WORLD JOURNAL OF GASTROENTEROLOGY; |
|
dc.identifier.uri |
http://repo.lib.semmelweis.hu//handle/123456789/450 |
|
dc.identifier.uri |
doi:10.3748/wjg.v19.i43.7701 |
|
dc.description.abstract |
AIM:
To analyze the difference in disease course and need for surgery in patients with Crohn's disease (CD).
METHODS:
Data of 506 patients with incident CD were analyzed (age at diagnosis: 31.5 ± 13.8 years). Both hospital and outpatient records were collected prospectively with a complete clinical follow-up and comprehensively reviewed in the population-based Veszprem province database, which includes incident CD patients diagnosed between January 1, 1977 and December 31, 2008. Follow-up data were collected until December 31, 2009. All patients included had at least 1 year of follow-up available. Patients with indeterminate colitis at diagnosis were excluded from the analysis.
RESULTS:
Overall, 73 patients (14.4%) required resective surgery within 1 year of diagnosis. Steroid exposure and need for biological therapy were lower in patients with early limited surgery (P < 0.001 and P = 0.09). In addition, surgery rates during follow-up in patients with and without early surgery differed significantly after matching on propensity scores (P < 0.001, HR = 0.23). The need for reoperation was also lower in patients with early limited resective surgery (P = 0.038, HR = 0.42) in a Kaplan-Meier and multivariate Cox regression (P = 0.04) analysis. However, this advantage was not observed after matching on propensity scores (P(Logrank) = 0.656, P(Breslow) = 0.498).
CONCLUSION:
Long-term surgery rates and overall exposure to steroids and biological agents were lower in patients with early limited resective surgery, but reoperation rates did not differ. |
|
dc.relation.ispartof |
urn:issn:1007-9327 |
|
dc.title |
Is early limited surgery associated with a more benign disease course in Crohn’s disease? |
|
dc.type |
Journal Article |
|
dc.date.updated |
2014-11-10T13:36:23Z |
|
dc.language.rfc3066 |
en |
|
dc.identifier.mtmt |
2400654 |
|
dc.identifier.wos |
000327519000023 |
|
dc.identifier.pubmed |
24282358 |
|
dc.contributor.department |
SE/ÁOK/K/I. Sz. Gyermekgyógyászati Klinika |
|
dc.contributor.department |
SE/ÁOK/K/I. Sz. Belgyógyászati Klinika |
|
dc.contributor.institution |
Semmelweis Egyetem |
|