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dc.contributor.author Dulic S
dc.contributor.author Vasarhelyi Z
dc.contributor.author Sava, Florentina
dc.contributor.author Berta, László Gergely
dc.contributor.author Szalay, Balázs
dc.contributor.author Toldi, Gergely
dc.contributor.author Kovács, László
dc.contributor.author Balog, Attila
dc.date.accessioned 2018-02-16T10:29:07Z
dc.date.available 2018-02-16T10:29:07Z
dc.date.issued 2017
dc.identifier.citation pagination=6894374, 19 pages; journalVolume=2017; journalTitle=MEDIATORS OF INFLAMMATION;
dc.identifier.uri http://repo.lib.semmelweis.hu//handle/123456789/4701
dc.identifier.uri doi:10.1155/2017/6894374
dc.description.abstract Data on the impact of biological therapies on the T-cell phenotype in rheumatoid arthritis are limited. Here, we prospectively measured the percentages of 15 circulating T-cell subtypes using flow cytometry. We obtained transversal and longitudinal data in 30 anti-TNF responders, 19 secondary anti-TNF nonresponders, and 43 IL-6R antagonist responders, before, 8 weeks and at least 6 months after biological therapy. Untreated RA patients and healthy controls were also included. The important findings are the following: ( 1) the proportion of regulatory T-cells (Tregs) which are decreased in untreated RA patients becomes normal in all long-term-treated groups; ( 2) in anti-TNF responders as well as in nonresponders, the frequencies of naive CD4+ and CD8+ cells are lower, whereas those of proinflammatory Th1, Th2, and Th17 cells and HLA-DR+-activated cells are higher than those in untreated RA or healthy controls; ( 3) in IL-6R responders, Th1 proportion is decreased, while that of Th2 and Th17 is increased as compared to that in anti-TNF-treated patients and controls; ( 4) pending confirmation, a CD4CD69 ratio <2.43 at baseline, could be useful to predict a good therapeutic response to anti-TNF therapy. This study provides comprehensive information regarding the long-term impacts of those biological therapies on the ecotaxis of T-cells in RA.
dc.relation.ispartof urn:issn:0962-9351
dc.title T-Cell Subsets in Rheumatoid Arthritis Patients on Long-Term Anti-TNF or IL-6 Receptor Blocker Therapy
dc.type Journal Article
dc.date.updated 2018-02-06T09:09:53Z
dc.language.rfc3066 en
dc.identifier.mtmt 3288491
dc.identifier.wos 000413592400001
dc.identifier.pubmed 29209104
dc.contributor.department SE/AOK/K/I. Sz. Gyermekgyógyászati Klinika
dc.contributor.department SE/AOK/K/I. Sz. Szülészeti és Nőgyógyászati Klinika
dc.contributor.institution Semmelweis Egyetem


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