Association of some rare haplotypes and genotype combinations in the MDR1 gene with childhood acute lymphoblastic leukaemia.

Association of some rare haplotypes and genotype combinations in the MDR1 gene with childhood acute lymphoblastic leukaemia.

Semsei, Ágnes F; Erdélyi, Dániel; Ungvári, Ildikó; Kamory E; Csokay B; Andrikovics, Hajnalka; Csagoly E; Tordai, Attila; Falus, András; Kovács, Gábor; Szalai, Csaba

Folyóiratcikk

LEUKEMIA RESEARCH vol.:32, issue.:8, p.:1214-1220.

ISSN: 0145-2126

URI: http://repo.lib.semmelweis.hu//handle/123456789/4783
https://doi.org/10.1016/j.leukres.2007.12.009

MTMT azonosító: 1176176

WoS ID: 000256251500008

PubMed ID: 18243305

Megjelenés éve: 2008

Kivonat:

To investigate their possible roles in disease susceptibility and some disease characteristics we genotyped C3435T and G2677T/A polymorphisms in multidrug resistance-1 (MDR1) gene with a single base extension method and the G34A and C421A polymorphisms of the breast cancer resistance protein gene with an allelic discrimination system in 396 children with acute lymphoblastic leukaemia (ALL) and 192 control patients. While the distribution of individual alleles and genotypes did not differ between patients and controls, there were significant differences in the frequencies of some rare haplotypes and genotype combinations in the MDR1 gene between the two groups.

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