Serum cholesterol and triglyceride levels in progeria as a model of ageing.

dc.contributor.author	Szamosi, Tamás
dc.contributor.author	Szollar J
dc.contributor.author	Meggyesi V
dc.contributor.author	Wilhelm O
dc.contributor.author	Bodánszky, Hedvig
dc.contributor.author	Matyus J
dc.date.accessioned	2018-10-12T08:15:27Z
dc.date.available	2018-10-12T08:15:27Z
dc.date.issued	1984
dc.identifier	0021720726
dc.identifier.citation	pagination=243-248; journalVolume=28; journalIssueNumber=2-3; journalTitle=MECHANISMS OF AGEING AND DEVELOPMENT;
dc.identifier.uri	http://repo.lib.semmelweis.hu//handle/123456789/4841
dc.identifier.uri	doi:10.1016/0047-6374(84)90024-1
dc.description.abstract	Hutchinson-Gilford progeria was observed in two brothers. Their parents, sister and other relatives did not show any signs of this illness. Serum total cholesterol and total triglyceride levels were normal in the whole family. The serum high density lipoprotein cholesterol (HDL-C) level of parents was low and that of boys was extremely low. The serum HDL-C level of the healthy sister and other relatives was normal. These findings in homozygous children and heterozygous parents may explain the development of the very early fatal arteriosclerosis described in this disease. The connection between the disorder of the lipid metabolism and progeria can serve as a useful model in the study of the role of lipid metabolism in normal ageing.
dc.relation.ispartof	urn:issn:0047-6374
dc.title	Serum cholesterol and triglyceride levels in progeria as a model of ageing.
dc.type	Journal Article
dc.date.updated	2018-02-19T12:08:28Z
dc.language.rfc3066	en
dc.identifier.mtmt	1614925
dc.identifier.wos	A1984TY17500011
dc.identifier.pubmed	6521505
dc.contributor.department	SE/AOK/K/II. Sz. Gyermekgyógyászati Klinika
dc.contributor.institution	Semmelweis Egyetem