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dc.contributor.author Goerlich KS
dc.contributor.author Votinov M
dc.contributor.author Dicks E
dc.contributor.author Ellendt S
dc.contributor.author Csukly, Gábor
dc.contributor.author Habel U
dc.date.accessioned 2018-06-21T08:05:12Z
dc.date.available 2018-06-21T08:05:12Z
dc.date.issued 2017
dc.identifier.citation pagination=34, pages: 12; journalVolume=9; journalTitle=FRONTIERS IN AGING NEUROSCIENCE;
dc.identifier.uri http://repo.lib.semmelweis.hu//handle/123456789/4904
dc.identifier.uri doi:10.3389/fnagi.2017.00034
dc.description.abstract Structural brain changes underlying mild cognitive impairment (MCI) have been well-researched, but most previous studies required subjective cognitive complaints (SCC) as a diagnostic criterion, diagnosed MCI based on a single screening test or lacked analyses in relation to neuropsychological impairment. This longitudinal voxel-based morphometry study aimed to overcome these limitations: The relationship between regional gray matter (GM) atrophy and behavioral performance was investigated over the course of 3 years in individuals unaware of cognitive decline, identified as amnestic MCI based on an extensive neuropsychological test battery. Region of interest analyses revealed GM atrophy in the left amygdala, hippocampus, and parahippocampus in MCI individuals compared to normally aging participants, which was specifically related to verbal memory impairment and evident already at the first measurement point. These findings demonstrate that GM atrophy is detectable in individuals with amnestic MCI despite unawareness of beginning cognitive decline. Thus, individuals with GM atrophy in regions associated with verbal memory impairment do not necessarily need to experience SCC before meeting neuropsychological criteria for MCI. These results have important implications for future research and diagnostic procedures of MCI.
dc.relation.ispartof urn:issn:1663-4365
dc.title Neuroanatomical and Neuropsychological Markers of Amnestic MCI: A Three-Year Longitudinal Study in Individuals Unaware of Cognitive Decline
dc.type Journal Article
dc.date.updated 2018-02-20T13:08:11Z
dc.language.rfc3066 en
dc.identifier.mtmt 3316321
dc.identifier.pubmed 28275349
dc.contributor.department SE/AOK/K/Pszichiátriai és Pszichoterápiás Klinika
dc.contributor.institution Semmelweis Egyetem
dc.mtmt.swordnote : 10.2174/1570159X15666171109143654.


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