dc.contributor.author |
Butykai, Ádám |
|
dc.contributor.author |
Orbánová, Agnesa |
|
dc.contributor.author |
Kocsis, Vilmos |
|
dc.contributor.author |
Szaller, Dávid |
|
dc.contributor.author |
Bordács, Sándor |
|
dc.contributor.author |
Tátrainé Szekeres, Erzsébet |
|
dc.contributor.author |
Kiss, László |
|
dc.contributor.author |
Bóta, Attila |
|
dc.contributor.author |
Vértessy, Beáta (Grolmuszné) |
|
dc.contributor.author |
Zelles, Tivadar |
|
dc.contributor.author |
Kézsmárki, István |
|
dc.date.accessioned |
2018-06-11T07:48:49Z |
|
dc.date.available |
2018-06-11T07:48:49Z |
|
dc.date.issued |
2013 |
|
dc.identifier |
84875204535 |
|
dc.identifier.citation |
pagination=1431, pages: 10;
journalVolume=3;
journalTitle=SCIENTIFIC REPORTS; |
|
dc.identifier.uri |
http://repo.lib.semmelweis.hu//handle/123456789/4912 |
|
dc.identifier.uri |
doi:10.1038/srep01431 |
|
dc.description.abstract |
The need to develop new methods for the high-sensitivity
diagnosis of malaria has initiated a global activity in medical
and interdisciplinary sciences. Most of the diverse variety of
emerging techniques are based on research-grade instruments,
sophisticated reagent-based assays or rely on expertise. Here,
we suggest an alternative optical methodology with an easy-to-
use and cost-effective instrumentation based on unique
properties of malaria pigment reported previously and determined
quantitatively in the present study. Malaria pigment, also
called hemozoin, is an insoluble microcrystalline form of heme.
These crystallites show remarkable magnetic and optical
anisotropy distinctly from any other components of blood. As a
consequence, they can simultaneously act as magnetically driven
micro-rotors and spinning polarizers in suspensions. These
properties can gain importance not only in malaria diagnosis and
therapies, where hemozoin is considered as drug target or immune
modulator, but also in the magnetic manipulation of cells and
tissues on the microscopic scale. |
|
dc.relation.ispartof |
urn:issn:2045-2322 |
|
dc.title |
Malaria pigment crystals as magnetic micro-rotors: Key for high-sensitivity diagnosis |
|
dc.type |
Journal Article |
|
dc.date.updated |
2018-02-20T13:22:32Z |
|
dc.language.rfc3066 |
en |
|
dc.identifier.mtmt |
2242098 |
|
dc.identifier.wos |
000315939200002 |
|
dc.identifier.pubmed |
23478535 |
|
dc.contributor.department |
MTA TTK/Molekuláris Farmakológiai Intézet [2013.12.31] |
|
dc.contributor.department |
MTA Wigner FK/Szilárdtestfizikai és Optikai Intézet |
|
dc.contributor.department |
MTA TTK/AKI/AKI jogelőd 2014 előtt [2014.12.31] |
|
dc.contributor.department |
BME/TTK/FI/FT/MTA-BME Kondenzált Anyagok Fizikája Kutatócsoport |
|
dc.contributor.department |
BME/TTK/FI/Fizika Tanszék |
|
dc.contributor.department |
BME/VBK/Alkalmazott Biotechnológia és Élelmiszertudományi Tanszék |
|
dc.contributor.department |
SE/FOK/Orálbiológiai Tanszék |
|
dc.contributor.institution |
MTA Természettudományi Kutatóközpont |
|
dc.contributor.institution |
MTA Wigner Fizikai Kutatóközpont |
|
dc.contributor.institution |
Budapesti Műszaki és Gazdaságtudományi Egyetem |
|
dc.contributor.institution |
Semmelweis Egyetem |
|