dc.contributor.author |
Gonda Xénia |
|
dc.contributor.author |
Eszlári Nóra |
|
dc.contributor.author |
Anderson IM |
|
dc.contributor.author |
Deakin JF |
|
dc.contributor.author |
Bagdy György |
|
dc.contributor.author |
Juhász Gabriella |
|
dc.date.accessioned |
2018-03-03T10:46:51Z |
|
dc.date.available |
2018-03-03T10:46:51Z |
|
dc.date.issued |
2016 |
|
dc.identifier |
85038006223 |
|
dc.identifier.citation |
pagination=e945, 8 pages;
journalVolume=6;
journalIssueNumber=11;
journalTitle=TRANSLATIONAL PSYCHIATRY; |
|
dc.identifier.uri |
http://repo.lib.semmelweis.hu//handle/123456789/4992 |
|
dc.identifier.uri |
doi:10.1038/tp.2016.221 |
|
dc.description.abstract |
Current understanding and treatment of depression is limited to the monoaminergic theory with little knowledge of the involvement of other cellular processes. Genome-wide association studies, however, implicate several novel single-nucleotide polymorphisms with weak but replicable effects and unclarified mechanisms. We investigated the effect of rs1106634 of the ATPV1B2 gene encoding the vacuolar H+ATPase on lifetime and current depression and the possible mediating role of neuroticism by logistic and linear regression in a white European general sample of 2226 subjects. Association of rs1106634 with performance on frontal (Stockings of Cambridge (SOC)) and hippocampal-dependent (paired associates learning (PAL)) cognitive tasks was investigated in multivariate general linear models in a smaller subsample. The ATP6V1B2 rs1106634 A allele had a significant effect on lifetime but not on current depression. The effect of the A allele on lifetime depression was not mediated by neuroticism. The A allele influenced performance on the PAL but not on the SOC test. We conclude that the effects of variation in the vacuolar ATPase may point to a new molecular mechanism that influences the long-term development of depression. This mechanism may involve dysfunction specifically in hippocampal circuitry and cognitive impairment that characterizes recurrent and chronic depression. |
|
dc.title |
Association of ATP6V1B2 rs1106634 with lifetime risk of depression and hippocampal neurocognitive deficits: possible novel mechanisms in the etiopathology of depression |
|
dc.type |
Journal Article |
|
dc.date.updated |
2018-02-23T08:25:16Z |
|
dc.language.rfc3066 |
en |
|
dc.identifier.mtmt |
3138408 |
|
dc.identifier.wos |
000392132700006 |
|
dc.identifier.pubmed |
27824360 |
|
dc.contributor.department |
SE/GYTK/GYHATAS/NAP-A-SE Új Antidepresszív Gyógyszercélpont Kutatócsoport |
|
dc.contributor.department |
SE/AOK/K/Pszichiátriai és Pszichoterápiás Klinika |
|
dc.contributor.department |
SE/GYTK/GYHATAS/MTA-SE Neuropszichofarmakológiai és Neurokémiai Kutatócsoport |
|
dc.contributor.department |
SE/GYTK/Gyógyszerhatástani Intézet |
|
dc.contributor.institution |
Semmelweis Egyetem |
|