dc.contributor.author |
Kiss, Zoltán |
|
dc.contributor.author |
Ambrus, Csaba |
|
dc.contributor.author |
Kulcsar I |
|
dc.contributor.author |
Szegedi J |
|
dc.contributor.author |
Kiss, István |
|
dc.contributor.author |
on behalf of the ACEGENE-BB_HU workgroup |
|
dc.date.accessioned |
2018-04-27T10:43:56Z |
|
dc.date.available |
2018-04-27T10:43:56Z |
|
dc.date.issued |
2015 |
|
dc.identifier |
84952950795 |
|
dc.identifier.citation |
pagination=1021-1027;
journalVolume=16;
journalIssueNumber=4;
journalTitle=JOURNAL OF THE RENIN-ANGIOTENSIN-ALDOSTERONE SYSTEM; |
|
dc.identifier.uri |
http://repo.lib.semmelweis.hu//handle/123456789/5171 |
|
dc.identifier.uri |
doi:10.1177/1470320314535276 |
|
dc.description.abstract |
BACKGROUND: Angiotensin-converting enzyme inhibitors (ACEis) improve survival; however, their effect on erythropoiesis remains a matter of debate in this population. Since insertion/deletion (I/D) polymorphism of the angiotensin-converting enzyme (ACE) gene largely influences serum ACE activity, its effect on erythropoiesis is also anticipated. METHOD: In this multicentre, cross-sectional study of 660 patients on maintenance haemodialysis, we analysed the effect of ACEi use and ACE gene I/D polymorphism on haemoglobin levels and erythropoietin resistance. Patients were allocated in groups based on genotype and ACEi therapy. We identified 128 matched pairs with I/I and D/D genotypes. RESULT: There was no difference in haemoglobin levels between genotype groups. Haemoglobin levels were lower in patients on ACEi therapy in the entire cohort (95.5+/-12.1 g/l vs 97.4+/-13.4 g/l, p=0.02) and patients with I/D (95.2+/-11 g/l vs 98.2+/-11.9 g/l, p=0.04) and D/D (93.3+/-13.2 g/l vs 97.4+/-14.2 g/l, p=0.02) genotypes. In patient pairs treated with ACEi therapy, subjects with D/D genotype had lower Haemoglobin level (93.0+/-12.8 g/l vs 98.2+/-11.9 g/l, p=0.006) and higher erythropoietin resistance index (ERI) (199.1 vs 175.0, p=0.046) than individuals with I/I genotype. CONCLUSION: These results indicate that ACEi therapy may increase erythropoietin resistance and worsen erythropoiesis in haemodialysis patients with the D allele. |
|
dc.relation.ispartof |
urn:issn:1470-3203 |
|
dc.title |
Effect of angiotensin-converting enzyme gene insertion/deletion polymorphism and angiotensin-converting enzyme inhibition on erythropoiesis in patients on haemodialysis. |
|
dc.type |
Journal Article |
|
dc.date.updated |
2018-03-17T20:15:57Z |
|
dc.language.rfc3066 |
en |
|
dc.identifier.mtmt |
2707912 |
|
dc.identifier.wos |
000367626500039 |
|
dc.identifier.pubmed |
25002133 |
|
dc.contributor.department |
SE/AOK/K/IISZBK/II. Sz. Belgyógyászati Klinika Geriátriai Tanszéki Csoport |
|
dc.contributor.institution |
Semmelweis Egyetem |
|