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dc.contributor.author Kovács Illés
dc.contributor.author Mihaltz Kata
dc.contributor.author Kránitz Kinga
dc.contributor.author Juhász Éva
dc.contributor.author Takács Ágnes Ildikó
dc.contributor.author Dienes Lóránt
dc.contributor.author Gergely Róbert
dc.contributor.author Nagy Zoltán Zsolt
dc.date.accessioned 2018-05-01T09:24:54Z
dc.date.available 2018-05-01T09:24:54Z
dc.date.issued 2016
dc.identifier 84962313344
dc.identifier.citation pagination=275-283; journalVolume=42; journalIssueNumber=2; journalTitle=JOURNAL OF CATARACT AND REFRACTIVE SURGERY;
dc.identifier.uri http://repo.lib.semmelweis.hu//handle/123456789/5312
dc.identifier.uri doi:10.1016/j.jcrs.2015.09.020
dc.description.abstract PURPOSE: To describe the topographic and tomographic characteristics of normal fellow eyes of unilateral keratoconus cases and to evaluate the accuracy of machine learning classifiers in discriminating healthy corneas from the normal fellow corneas. SETTING: Department of Ophthalmology, Semmelweis University, Budapest, Hungary. DESIGN: Retrospective case-control study. METHODS: Patients with bilateral keratoconus (keratoconus group), clinically and according to the keratoconus indices of the Pentacam HR Scheimpflug camera; normal fellow eyes of patients with unilateral keratoconus (fellow-eye group); and eyes of refractive surgery candidates (control group) were compared. Tomographic data, topographic data, and keratoconus indices were measured in both eyes using the Scheimpflug camera. Receiver operating characteristic (ROC) analysis was used to assess the performance of automated classifiers trained on bilateral data as well as individual parameters to discriminate fellow eyes of patients with keratoconus from control eyes. RESULTS: Keratometry, elevation, and keratoconus indices values were significantly higher and pachymetry values were significantly lower in keratoconus eyes than in fellow eyes of unilateral keratoconus cases (P < .001). These fellow eyes had significantly higher keratometry, elevation, and keratoconus index values and significantly lower pachymetry values than control eyes (P < .001). Automated classifiers trained on bilateral data of index of height decentration had higher accuracy than the unilateral single parameter in discriminating fellow eyes of patients with keratoconus from control eyes (area under ROC 0.96 versus 0.88). CONCLUSION: Automatic classifiers trained on bilateral data were better than single parameters in discriminating fellow eyes of patients with unilateral keratoconus with preclinical signs of keratoconus from normal eyes. FINANCIAL DISCLOSURE: No author has a financial or proprietary interest in any material or method mentioned.
dc.relation.ispartof urn:issn:0886-3350
dc.title Accuracy of machine learning classifiers using bilateral data from a Scheimpflug camera for identifying eyes with preclinical signs of keratoconus.
dc.type Journal Article
dc.date.updated 2018-04-30T20:20:52Z
dc.language.rfc3066 en
dc.identifier.mtmt 3068739
dc.identifier.wos 000373315300015
dc.identifier.pubmed 27026453
dc.contributor.department SE/AOK/K/Szemészeti Klinika
dc.contributor.institution Semmelweis Egyetem


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