Egyszerű nézet

dc.contributor.author Tóth Georgina
dc.contributor.author Racz A
dc.contributor.author Tárnoki Ádám Domonkos
dc.contributor.author Tárnoki Dávid László
dc.contributor.author Szekelyhidi Z
dc.contributor.author Süveges Ildikó
dc.contributor.author Németh János Tibor
dc.contributor.author Nagy Zoltán Zsolt
dc.date.accessioned 2018-05-01T10:35:33Z
dc.date.available 2018-05-01T10:35:33Z
dc.date.issued 2014
dc.identifier 84914692236
dc.identifier.citation pagination=397-404; journalVolume=17; journalIssueNumber=5; journalTitle=TWIN RESEARCH AND HUMAN GENETICS;
dc.identifier.uri http://repo.lib.semmelweis.hu//handle/123456789/5326
dc.identifier.uri doi:10.1017/thg.2014.54
dc.description.abstract BACKGROUND: Few, and inconsistent, studies have showed high heritability of some parameters of the anterior segment of the eye; however, no heritability of anterior chamber volume (ACV) has been reported, and no study has been performed to investigate the correlation between the ACV and central corneal thickness (CCT). METHODS: Anterior segment measurements (Pentacam, Oculus) were obtained from 220 eyes of 110 adult Hungarian twins (41 monozygotic and 14 same-sex dizygotic pairs; 80% women; age 48.6 +/- 15.5 years) obtained from the Hungarian Twin Registry. RESULTS: Age- and sex-adjusted heritability of ACV was 85% (bootstrapped 95% confidence interval; CI: 69% to 93%), and 88% for CCT (CI: 79% to 95%). Common environmental effects had no influence, and unshared environmental factors were responsible for 12% and 15% of the variance, respectively. The correlation between ACV and CCT was negative and significant (r ph = -0.35, p < .05), and genetic factors accounted for the covariance significantly (0.934; CI: 0.418, 1.061) based on the bivariate Cholesky decomposition model. CONCLUSION: These findings support the high heritability of ACV and central corneal thickness, and a strong genetic covariance between them, which underscores the importance of identification of the specific genetic factors and the family risk-based screening of disorders related to these variables, such as open-angle and also angle closure glaucoma and corneal endothelial alterations.
dc.relation.ispartof urn:issn:1832-4274
dc.title Genetic covariance between central corneal thickness and anterior chamber volume: a hungarian twin study.
dc.type Journal Article
dc.date.updated 2018-05-01T08:37:44Z
dc.language.rfc3066 en
dc.identifier.mtmt 2754277
dc.identifier.wos 000343964200007
dc.identifier.pubmed 25300003
dc.contributor.department SE/AOK/K/Radiológiai és Onkoterápiás Klinika
dc.contributor.department SE/AOK/K/Szemészeti Klinika
dc.contributor.institution Semmelweis Egyetem


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