dc.contributor.author |
Tóth Georgina |
|
dc.contributor.author |
Racz A |
|
dc.contributor.author |
Tárnoki Ádám Domonkos |
|
dc.contributor.author |
Tárnoki Dávid László |
|
dc.contributor.author |
Szekelyhidi Z |
|
dc.contributor.author |
Süveges Ildikó |
|
dc.contributor.author |
Németh János Tibor |
|
dc.contributor.author |
Nagy Zoltán Zsolt |
|
dc.date.accessioned |
2018-05-01T10:35:33Z |
|
dc.date.available |
2018-05-01T10:35:33Z |
|
dc.date.issued |
2014 |
|
dc.identifier |
84914692236 |
|
dc.identifier.citation |
pagination=397-404;
journalVolume=17;
journalIssueNumber=5;
journalTitle=TWIN RESEARCH AND HUMAN GENETICS; |
|
dc.identifier.uri |
http://repo.lib.semmelweis.hu//handle/123456789/5326 |
|
dc.identifier.uri |
doi:10.1017/thg.2014.54 |
|
dc.description.abstract |
BACKGROUND: Few, and inconsistent, studies have showed high heritability of some parameters of the anterior segment of the eye; however, no heritability of anterior chamber volume (ACV) has been reported, and no study has been performed to investigate the correlation between the ACV and central corneal thickness (CCT). METHODS: Anterior segment measurements (Pentacam, Oculus) were obtained from 220 eyes of 110 adult Hungarian twins (41 monozygotic and 14 same-sex dizygotic pairs; 80% women; age 48.6 +/- 15.5 years) obtained from the Hungarian Twin Registry. RESULTS: Age- and sex-adjusted heritability of ACV was 85% (bootstrapped 95% confidence interval; CI: 69% to 93%), and 88% for CCT (CI: 79% to 95%). Common environmental effects had no influence, and unshared environmental factors were responsible for 12% and 15% of the variance, respectively. The correlation between ACV and CCT was negative and significant (r ph = -0.35, p < .05), and genetic factors accounted for the covariance significantly (0.934; CI: 0.418, 1.061) based on the bivariate Cholesky decomposition model. CONCLUSION: These findings support the high heritability of ACV and central corneal thickness, and a strong genetic covariance between them, which underscores the importance of identification of the specific genetic factors and the family risk-based screening of disorders related to these variables, such as open-angle and also angle closure glaucoma and corneal endothelial alterations. |
|
dc.relation.ispartof |
urn:issn:1832-4274 |
|
dc.title |
Genetic covariance between central corneal thickness and anterior chamber volume: a hungarian twin study. |
|
dc.type |
Journal Article |
|
dc.date.updated |
2018-05-01T08:37:44Z |
|
dc.language.rfc3066 |
en |
|
dc.identifier.mtmt |
2754277 |
|
dc.identifier.wos |
000343964200007 |
|
dc.identifier.pubmed |
25300003 |
|
dc.contributor.department |
SE/AOK/K/Radiológiai és Onkoterápiás Klinika |
|
dc.contributor.department |
SE/AOK/K/Szemészeti Klinika |
|
dc.contributor.institution |
Semmelweis Egyetem |
|