dc.contributor.author |
Vereckei, András |
|
dc.contributor.author |
Szelényi, Zsuzsanna Orsolya |
|
dc.contributor.author |
Kutyifa, Valentina |
|
dc.contributor.author |
Zima, Endre István |
|
dc.contributor.author |
Szénási, Gábor |
|
dc.contributor.author |
Kiss M |
|
dc.contributor.author |
Katona, Gábor |
|
dc.contributor.author |
Karádi, István |
|
dc.contributor.author |
Merkely, Béla Péter |
|
dc.date.accessioned |
2018-06-15T11:05:19Z |
|
dc.date.available |
2018-06-15T11:05:19Z |
|
dc.date.issued |
2018 |
|
dc.identifier.citation |
pagination=97-103;
journalVolume=20;
journalIssueNumber=1;
journalTitle=EUROPACE; |
|
dc.identifier.uri |
http://repo.lib.semmelweis.hu//handle/123456789/5365 |
|
dc.identifier.uri |
doi:10.1093/europace/euw326 |
|
dc.description.abstract |
AIMS: We hypothesized that the greater the intra- or interventricular dyssynchrony (intraD, interD), the more effective cardiac resynchronization therapy (CRT) is. We sought to improve patient selection for CRT by using novel ECG dyssynchrony criteria. METHODS AND RESULTS: Left ventricular (LV) intraD was estimated by the absolute time difference between the intrinsicoid deflections (ID) in leads aVL and aVF divided by the QRS duration (QRSd): [aVLID - aVFID]/QRSd (%). InterD was estimated from the formula: [V5ID - V1ID]/QRSd (%). Their >25% value indicated electrical dyssynchrony present (ED+) and </=25% value electrical dyssynchrony absent (ED-) diagnoses. Using the intraD + interD criteria (intra + interDC) together, if at least one of them indicated ED+ diagnosis, a final ED+ diagnosis, if both indicated ED- diagnosis, a final ED- diagnosis was made. Two authors, blinded to CRT response, retrospectively analysed pre-CRT ECGs of 124 patients with known CRT outcome. CRT response was defined as improvement of >/= 1 NYHA class, being alive and having no hospitalizations for heart failure during 6 months of follow-up. 35/124 (28%) patients were non-responders (NRs), using the traditional criteria (TC) correct diagnosis was made in the remaining 89/124 (72%) responder (R) cases. The test accuracy (TA) of intra + interDC + TC [100/124 (81%), P < 0.001] was superior to that of TC [89/124 (72%)] due to its superior TA [36/43 (84%) vs. 29/43 (67%), respectively, P = 0.0156] in the non-specific intra-ventricular conduction disturbance (NICD) subgroup [43/124 (35%)]. In the left bundle branch block subgroup [70/124 (56%)] there was no between-criteria difference in TA. CONCLUSION: The intra + interDC + TC predicts clinical response after CRT more accurately than TC alone, due to greater TA in the NICD subgroup. |
|
dc.relation.ispartof |
urn:issn:1099-5129 |
|
dc.title |
Novel electrocardiographic dyssynchrony criteria improve patient selection for cardiac resynchronization therapy |
|
dc.type |
Journal Article |
|
dc.date.updated |
2018-05-05T23:58:44Z |
|
dc.language.rfc3066 |
en |
|
dc.identifier.mtmt |
3158791 |
|
dc.identifier.wos |
000419659300016 |
|
dc.identifier.pubmed |
28011802 |
|
dc.contributor.department |
SE/AOK/K/III. Sz. Belgyógyászati Klinika |
|
dc.contributor.department |
SE/AOK/K/VAROSMAJOR_SZÍVÉRGYÓGY/Kardiológia Központ - Kardiológiai Tanszék |
|
dc.contributor.department |
SE/AOK/I/Kórélettani Intézet |
|
dc.contributor.institution |
Semmelweis Egyetem |
|