dc.contributor.author |
Daruházi, Ágnes Emma |
|
dc.contributor.author |
Kiss T, |
|
dc.contributor.author |
Vecsernyés, Miklós |
|
dc.contributor.author |
Szente, Lajos |
|
dc.contributor.author |
Szőke, Éva |
|
dc.contributor.author |
Lemberkovics, Éva |
|
dc.date.accessioned |
2014-11-16T17:17:48Z |
|
dc.date.available |
2014-11-16T17:17:48Z |
|
dc.date.issued |
2013 |
|
dc.identifier.citation |
pagination=112-116;
journalVolume=84;
journalTitle=JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS; |
|
dc.identifier.uri |
http://repo.lib.semmelweis.hu//handle/123456789/537 |
|
dc.identifier.uri |
doi:10.1016/j.jpba.2013.05.012 |
|
dc.description.abstract |
Isoflavonoids are widespread constituents in medical plants especially in legumes (Fabaceae), but occur in other different plant families as well (Rosaceae, Iridaceae, Amaranthaceae). Their antioxidant, estrogen-like, anti-inflammatory and analgesic effects make them promising compounds in therapy of important disorders especially in estrogen related diseases. Poor solubility in aqueous system of genistein and daidzein needs a solubility enhancement for pharmaceutical use. These compounds are suitable guest molecules for inclusion complex formation with cyclodextrins (CDs) considering matching their size and polarity. The molecular encapsulation with beta-cyclodextrin (beta-CD), gamma-cyclodextrin (gamma-CD), hydroxypropyl-beta-cyclodextrin (HP-beta-CD) and random methyl-beta cyclodextrin (RAMEB-CD) results in a solid, molecularly dispersed form and in a significantly improved aqueous solubility of genistein and daidzein. Determining enhancement in solubility and bioavailability we investigated the transport of these inclusion complexes across Caco-2 cell line comparing that of the pure compounds and found significant improving effect of the different CD derivatives on membrane permeation of the two isoflavone aglycons. |
|
dc.relation.ispartof |
urn:issn:0731-7085 |
|
dc.title |
Investigation of transport of genistein, daidzein and their inclusion complexes prepared with different cyclodextrins on Caco-2 cell line. |
|
dc.type |
Journal Article |
|
dc.date.updated |
2014-11-16T17:17:16Z |
|
dc.language.rfc3066 |
en |
|
dc.identifier.mtmt |
2361307 |
|
dc.identifier.pubmed |
23810850 |
|
dc.contributor.department |
SE/GYTK/Farmakognózia Intézet |
|
dc.contributor.institution |
Semmelweis Egyetem |
|