Separation and identification of tofisopam stereoisomers by hyphenated HPLC-CD technique

dc.contributor.author	Zsila Ferenc
dc.contributor.author	Gergely András
dc.contributor.author	Horváth Péter
dc.contributor.author	Szász György
dc.date.accessioned	2018-07-30T15:20:53Z
dc.date.available	2018-07-30T15:20:53Z
dc.date.issued	1999
dc.identifier	0032946249
dc.identifier.citation	pagination=713-719; journalVolume=22; journalIssueNumber=5; journalTitle=JOURNAL OF LIQUID CHROMATOGRAPHY & RELATED TECHNOLOGIES;
dc.identifier.uri	http://repo.lib.semmelweis.hu//handle/123456789/5470
dc.identifier.uri	doi:10.1081/JLC-100101693
dc.description.abstract	The published method allows the separation of the four isomers of the anxiolytic 2,3-diazepine derivative, tofisopam. Assignment for the peaks of the two central and two helical isomers is performed by using the chromatogram of the pure tofisopam enantiomers and also considering the conformer-equilibrium was suggested by previous authors. The detection has been made by CD. The in situ CD spectra of the peaks, obtained by stop-flow method, definitely show different chiral character.
dc.relation.ispartof	urn:issn:1082-6076
dc.title	Separation and identification of tofisopam stereoisomers by hyphenated HPLC-CD technique
dc.type	Journal Article
dc.date.updated	2018-05-28T07:09:00Z
dc.language.rfc3066	en
dc.identifier.mtmt	1071380
dc.identifier.wos	000079276700007
dc.contributor.department	SE/GYTK/Gyógyszerészi Kémiai Intézet
dc.contributor.institution	Semmelweis Egyetem