Study on SSAO enzyme activity and anti-inflammatory effect of SSAO inhibitors in animal model of inflammation.

dc.contributor.author	Tábi, Tamás
dc.contributor.author	Szökő, Éva
dc.contributor.author	Merey A,
dc.contributor.author	Tóth, Veronika
dc.contributor.author	Mátyus, Péter
dc.contributor.author	Gyires, Klára
dc.date.accessioned	2014-11-16T19:19:57Z
dc.date.available	2014-11-16T19:19:57Z
dc.date.issued	2013
dc.identifier	84878741283
dc.identifier.citation	pagination=963-967; journalVolume=120; journalIssueNumber=6; journalTitle=JOURNAL OF NEURAL TRANSMISSION;
dc.identifier.uri	http://repo.lib.semmelweis.hu//handle/123456789/557
dc.identifier.uri	doi:10.1007/s00702-012-0961-1
dc.description.abstract	SSAO/VAP-1 participates in the accumulation of leukocytes at the site of inflammation. A new SSAO inhibitor, SzV-1287 was demonstrated to inhibit both acute and chronic inflammation in rats more effectively than the known enzyme inhibitor, LJP-1207. Surprisingly, the SSAO activity was not increased, but decreased both in acute and chronic inflammation. Though experiments are in progress to clarify these findings, the enzyme might play a role in the very early phase of inflammation and be inactivated during leukocyte extravasation.
dc.relation.ispartof	urn:issn:0300-9564
dc.title	Study on SSAO enzyme activity and anti-inflammatory effect of SSAO inhibitors in animal model of inflammation.
dc.type	Journal Article
dc.date.updated	2014-11-16T19:19:06Z
dc.language.rfc3066	en
dc.identifier.mtmt	2197197
dc.identifier.wos	000319433000016
dc.identifier.pubmed	23263543
dc.contributor.department	SE/ÁOK/K/Bőr-, Nemikórtani és Bőronkológiai Klinika
dc.contributor.department	SE/GYTK/Gyógyszerhatástani Intézet
dc.contributor.institution	Semmelweis Egyetem