Egyszerű nézet

dc.contributor.author Kubinyi, Enikő
dc.contributor.author Bence M
dc.contributor.author Koller D
dc.contributor.author Wan M
dc.contributor.author Pergel E
dc.contributor.author Rónai, Zsolt
dc.contributor.author Sasvári-Székely, Mária
dc.contributor.author Miklósi, Ádám
dc.date.accessioned 2018-06-21T08:49:48Z
dc.date.available 2018-06-21T08:49:48Z
dc.date.issued 2017
dc.identifier 85028983101
dc.identifier.citation pagination=1520, pages: 8; journalVolume=8; journalTitle=FRONTIERS IN PSYCHOLOGY;
dc.identifier.uri http://repo.lib.semmelweis.hu//handle/123456789/5585
dc.identifier.uri doi:10.3389/fpsyg.2017.01520
dc.description.abstract Meeting humans is an everyday experience for most companion dogs, and their behavior in these situations and its genetic background is of major interest. Previous research in our laboratory reported that in German shepherd dogs the lack of G allele, and in Border collies the lack of A allele, of the oxytocin receptor gene (OXTR) 19208A/G single nucleotide polymorphism (SNP) was linked to increased friendliness, which suggests that although broad traits are affected by genetic variability, the specific links between alleles and behavioral variables might be breed-specific. In the current study, we found that Siberian huskies with the A allele approached a friendly unfamiliar woman less frequently in a greeting test, which indicates that certain polymorphisms are related to human directed behavior, but that the relationship patterns between polymorphisms and behavioral phenotypes differ between populations. This finding was further supported by our next investigation. According to primate studies, endogenous opioid peptide (e.g., endorphins) receptor genes have also been implicated in social relationships. Therefore, we examined the rs21912990 of the OPRM1 gene. Firstly, we found that the allele frequencies of Siberian huskies and gray wolves were similar, but differed from that of Border collies and German shepherd dogs, which might reflect their genetic relationship. Secondly, we detected significant associations between the OPRM1 SNP and greeting behavior among German shepherd dogs and a trend in Border collies, but we could not detect an association in Siberian huskies. Although our results with OXTR and OPRM1 gene variants should be regarded as preliminary due to the relatively low sample size, they suggest that (1) OXTR and OPRM1 gene variants in dogs affect human-directed social behavior and (2) their effects differ between breeds.
dc.relation.ispartof urn:issn:1664-1078
dc.title Oxytocin and Opioid Receptor Gene Polymorphisms Associated with Greeting Behavior in Dogs
dc.type Journal Article
dc.date.updated 2018-06-08T12:55:33Z
dc.language.rfc3066 en
dc.identifier.mtmt 3291101
dc.identifier.wos 000409522300001
dc.identifier.pubmed 28936190


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