Kivonat:
It is suggested that tumour stromal myofibroblasts exert an
unfavourable effect on the biology of breast cancer. We are
aware of only a single study which examined relationships
between manifestation of myofibroblasts in the stroma of breast
cancer and clinicopathological data of the patients. The present
study was aimed at estimation of the effect exerted by
myofibroblasts present in the tumour stroma on principal
pathological parameters and on expression of Ki67, P53 and HER-2
proteins in the group of the most frequent breast cancers, the
ductal cancers. In paraffin sections of 60 ductal breast cancers
(20 cases in G1, 20 in G2 and 20 in G3), immunohistochemical
reactions were performed to detect expression of smooth muscle
actin (SMA) in order to visualize myofibroblasts, Ki67, P53 and
HER-2. The studies demonstrated that the most numerous
myofibroblasts were present in G3 cases and they were the least
frequent in G1 cases (P = 0.02). Positive correlations were
observed between the presence of myofibroblasts in tumour stroma
and expression of Ki67 and HER-2 in breast cancer cells in the
entire group (P < 0.001 and P = 0.001, respectively), in G2
cases (P = 0.003 and P = 0.03) and in G3 cases (P = 0.01 and P =
0.03). Considering that the higher grade, Ki67 and HER-2 are
thought to represent unfavourable prognostic factors, the
elevated content of myofibroblasts in tumour stroma is probably
typical for cases with worse prognosis.
