dc.contributor.author |
Rosta, Klára |
|
dc.contributor.author |
Al-Aissa, Zahra |
|
dc.contributor.author |
Hadarits, Orsolya |
|
dc.contributor.author |
Harreiter J |
|
dc.contributor.author |
Nádasdi, Ákos |
|
dc.contributor.author |
Kelemen F |
|
dc.contributor.author |
Bancher-Todesca D |
|
dc.contributor.author |
Komlósi, Zsolt |
|
dc.contributor.author |
Németh, László |
|
dc.contributor.author |
Rigó, János |
|
dc.contributor.author |
Sziller I |
|
dc.contributor.author |
Somogyi, Anikó |
|
dc.contributor.author |
Kautzky-Willer A |
|
dc.contributor.author |
Firneisz, Gábor |
|
dc.date.accessioned |
2018-09-17T06:47:24Z |
|
dc.date.available |
2018-09-17T06:47:24Z |
|
dc.date.issued |
2017 |
|
dc.identifier |
85009077510 |
|
dc.identifier.citation |
pagination=e0169781, pages: 17;
journalVolume=12;
journalIssueNumber=1;
journalTitle=PLOS ONE; |
|
dc.identifier.uri |
http://repo.lib.semmelweis.hu//handle/123456789/5966 |
|
dc.identifier.uri |
doi:10.1371/journal.pone.0169781 |
|
dc.description.abstract |
CONTEXT: Genetic variation in human maternal DNA contributes to the susceptibility for development of gestational diabetes mellitus (GDM). OBJECTIVE: We assessed 77 maternal single nucleotide gene polymorphisms (SNPs) for associations with GDM or plasma glucose levels at OGTT in pregnancy. METHODS: 960 pregnant women (after dropouts 820: case/control: m99'WHO: 303/517, IADPSG: 287/533) were enrolled in two countries into this case-control study. After genomic DNA isolation the 820 samples were collected in a GDM biobank and assessed using KASP (LGC Genomics) genotyping assay. Logistic regression risk models were used to calculate ORs according to IADPSG/m'99WHO criteria based on standard OGTT values. RESULTS: The most important risk alleles associated with GDM were rs10830963/G of MTNR1B (OR = 1.84/1.64 [IADPSG/m'99WHO], p = 0.0007/0.006), rs7754840/C (OR = 1.51/NS, p = 0.016) of CDKAL1 and rs1799884/T (OR = 1.4/1.56, p = 0.04/0.006) of GCK. The rs13266634/T (SLC30A8, OR = 0.74/0.71, p = 0.05/0.02) and rs7578326/G (LOC646736/IRS1, OR = 0.62/0.60, p = 0.001/0.006) variants were associated with lower risk to develop GDM. Carrying a minor allele of rs10830963 (MTNR1B); rs7903146 (TCF7L2); rs1799884 (GCK) SNPs were associated with increased plasma glucose levels at routine OGTT. CONCLUSIONS: We confirmed the robust association of MTNR1B rs10830963/G variant with GDM binary and glycemic traits in this Caucasian case-control study. As novel associations we report the minor, G allele of the rs7578326 SNP in the LOC646736/IRS1 region as a significant and the rs13266634/T SNP (SLC30A8) as a suggestive protective variant against GDM development. Genetic susceptibility appears to be more preponderant in individuals who meet both the modified 99'WHO and the IADPSG GDM diagnostic criteria. |
|
dc.relation.ispartof |
urn:issn:1932-6203 |
|
dc.title |
Association Study with 77 SNPs Confirms the Robust Role for the rs10830963/G of MTNR1B Variant and Identifies Two Novel Associations in Gestational Diabetes Mellitus Development |
|
dc.type |
Journal Article |
|
dc.date.updated |
2018-07-20T06:47:11Z |
|
dc.language.rfc3066 |
en |
|
dc.identifier.mtmt |
3166169 |
|
dc.identifier.wos |
000391844200045 |
|
dc.identifier.pubmed |
28072873 |
|
dc.contributor.department |
SE/AOK/K/II. Sz. Belgyógyászati Klinika |
|
dc.contributor.department |
SE/AOK/K/I. Sz. Szülészeti és Nőgyógyászati Klinika |
|
dc.contributor.department |
SE/AOK/K/Pulmonológiai Klinika |
|
dc.contributor.department |
SE/AOK/K/IISZBK/MTA-SE Molekuláris Medicina Kutatócsoport (2006-ig: MTA-SE Gastroenterológiai és Endocrinológiai Kutatócsoport) |
|
dc.contributor.department |
ELTE/TTK/Biológiai Intézet |
|
dc.contributor.institution |
Semmelweis Egyetem |
|
dc.contributor.institution |
Eötvös Loránd Tudományegyetem |
|