Show simple item record Egea J Fabregat I Frapart YM Ghezzi P Gorlach A Kietzmann T Kubaichuk K Knaus UG Lopez MG Olaso-Gonzalez G Petry A Schulz R Vina J Winyard P Abbas K Ademowo OS Afonso CB Andreadou I Antelmann H Antunes F Aslan M Bachschmid MM Barbosa RM Belousov V Berndt C Bernlohr D Bertran E Bindoli A Bottari SP Brito PM Carrara G Casas AI Chatzi A; Chondrogianni N Conrad M Cooke MS Costa JG Cuadrado A My-Chan Dang P De Smet B Debelec-Butuner B Dias IHK Dunn JD Edson AJ El Assar M El-Benna J Ferdinandy, Péter Fernandes AS Fladmark KE Forstermann U Giniatullin R Giricz, Zoltán Görbe, Anikó Griffiths H Hampl V Hanf A Herget J Hernansanz-Agustin P Hillion M Huang J Ilikay S Jansen-Durr P Jaquet V Joles JA Kalyanaraman B Kaminskyy D Karbaschi M Kleanthous M Klotz LO Korac B Korkmaz KS Koziel R Kracun D Krause KH Kren V Krieg T Laranjinha J Lazou A Li H Martinez-Ruiz A Matsui R McBean GJ Meredith SP Messens J Miguel V Mikhed Y Milisav I Milkovic L Miranda-Vizuete A Mojovic M Monsalve M Mouthuy PA Mulvey J Munzel T Muzykantov V Nguyen ITN Oelze M Oliveira NG Palmeira CM Papaevgeniou N Pavicevic A Pedre B Peyrot F Phylactides M Pircalabioru GG Pitt AR Poulsen HE Prieto I Rigobello MP Robledinos-Anton N Rodriguez-Manas L Rolo AP Rousset F Ruskovska T Saraiva N Sasson S Schroder K Semen K Seredenina T Shakirzyanova A Smith GL Soldati T Sousa BC Spickett CM Stancic A Stasia MJ Steinbrenner H Stepanic V Steven S Tokatlidis K Tuncay E Turan B Ursini F Vacek J Vajnerova O Valentova K Van Breusegem F Varisli L Veal EA Yalcin AS Yelisyeyeva O Zarkovic N Zatloukalova M Zielonka J Touyz RM Papapetropoulos A Grune T Lamas S Schmidt HHHW Di Lisa F Daiber A 2018-09-21T08:07:05Z 2018-09-21T08:07:05Z 2017
dc.identifier 85020032301
dc.identifier.citation pagination=94-162; journalVolume=13; journalTitle=REDOX BIOLOGY;
dc.identifier.uri doi:10.1016/j.redox.2017.05.007
dc.description.abstract The European Cooperation in Science and Technology (COST) provides an ideal framework to establish multi-disciplinary research networks. COST Action BM1203 (EU-ROS) represents a consortium of researchers from different disciplines who are dedicated to providing new insights and tools for better understanding redox biology and medicine and, in the long run, to finding new therapeutic strategies to target dysregulated redox processes in various diseases. This report highlights the major achievements of EU-ROS as well as research updates and new perspectives arising from its members. The EU-ROS consortium comprised more than 140 active members who worked together for four years on the topics briefly described below. The formation of reactive oxygen and nitrogen species (RONS) is an established hallmark of our aerobic environment and metabolism but RONS also act as messengers via redox regulation of essential cellular processes. The fact that many diseases have been found to be associated with oxidative stress established the theory of oxidative stress as a trigger of diseases that can be corrected by antioxidant therapy. However, while experimental studies support this thesis, clinical studies still generate controversial results, due to complex pathophysiology of oxidative stress in humans. For future improvement of antioxidant therapy and better understanding of redox-associated disease progression detailed knowledge on the sources and targets of RONS formation and discrimination of their detrimental or beneficial roles is required. In order to advance this important area of biology and medicine, highly synergistic approaches combining a variety of diverse and contrasting disciplines are needed.
dc.title European contribution to the study of ROS: A summary of the findings and prospects for the future from the COST action BM1203 (EU-ROS)
dc.type Journal Article 2018-08-27T18:30:16Z
dc.language.rfc3066 en
dc.identifier.mtmt 3235821
dc.identifier.wos 000410470000009
dc.identifier.pubmed 28577489
dc.contributor.department SE/AOK/I/Farmakológiai és Farmakoterápiás Intézet
dc.contributor.institution Semmelweis Egyetem

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