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dc.contributor.author Szegedi, Róbert
dc.contributor.author Széplaki, Gábor
dc.contributor.author Varga, Lilian
dc.contributor.author Prohászka, Zoltán
dc.contributor.author Szeplaki Z
dc.contributor.author Karádi, István
dc.contributor.author Füst, György
dc.contributor.author Farkas, Henriette
dc.date.accessioned 2018-10-10T12:57:06Z
dc.date.available 2018-10-10T12:57:06Z
dc.date.issued 2008
dc.identifier 40949141935
dc.identifier.citation pagination=184-191; journalVolume=198; journalIssueNumber=1; journalTitle=ATHEROSCLEROSIS;
dc.identifier.uri http://repo.lib.semmelweis.hu//handle/123456789/6384
dc.identifier.uri doi:10.1016/j.atherosclerosis.2007.09.025
dc.description.abstract BACKGROUND: Hereditary angioedema (HAE) is characterized by episodic edematous attacks due to the deficiency of the C1-inhibitor (C1-INH). Recently, we have described that the long-term use of danazol affects lipid metabolism, resulting in decreased high-density lipoprotein (HDL) and increased low-density lipoprotein (LDL) cholesterol levels, which might lead to accelerated, early atherosclerosis. Our aim in the present study was to investigate the impact of danazol treatment on the risk of atherosclerosis in HAE patients. METHODS: The prevalence of vascular disease, as well as carotid intima-media thickness (IMT)--an objective marker of atherosclerosis--was determined in 32 HAE patients undergoing danazol prophylaxis, and compared to 25 HAE patients without danazol treatment, as well as to 20 healthy controls. Distinct atherosclerosis risk profiles were determined in addition. RESULTS: HAE patients with danazol prophylaxis had higher body mass index (p=0.0055 and 0.0020), creatinine (p=0.0001 and 0.0130), alanine aminotransferase (p=0.0298 and 0.0457), LDL (p=0.0060 and <0.0001) and decreased HDL (p<0.0001 and <0.0001) levels compared to both control groups. The prevalence of vascular diseases did not differ in the two patient groups. No significant differences were observed in mean (0.43 (0.37-0.50)mm vs. 0.40 (0.35-0.49)mm, p=0.5465) carotid IMT values, when comparing patients with or without long-term danazol prophylaxis. CONCLUSIONS: Thickening of IMT due to danazol use was not observed in HAE patients. We hypothesize that the functional deficiency of C1-INH might confer protection against atherosclerosis in these patients.
dc.relation.ispartof urn:issn:0021-9150
dc.title Long-term danazol prophylaxis does not lead to increased carotid intima-media thickness in hereditary angioedema patients.
dc.type Journal Article
dc.date.updated 2018-09-02T10:11:40Z
dc.language.rfc3066 en
dc.identifier.mtmt 1297178
dc.identifier.wos 000255491800023
dc.identifier.pubmed 17977544
dc.contributor.department SE/AOK/K/III. Sz. Belgyógyászati Klinika
dc.contributor.institution Semmelweis Egyetem
dc.mtmt.swordnote Megosztott első szerzőség (Szegedi R és Széplaki G).


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