dc.contributor.author |
Madách, Krisztina |
|
dc.contributor.author |
Molvarec, Attila |
|
dc.contributor.author |
Rigó, János |
|
dc.contributor.author |
Nagy, Bálint |
|
dc.contributor.author |
Pénzes, István |
|
dc.contributor.author |
Karádi, István |
|
dc.contributor.author |
Prohászka, Zoltán |
|
dc.date.accessioned |
2018-10-08T09:51:00Z |
|
dc.date.available |
2018-10-08T09:51:00Z |
|
dc.date.issued |
2008 |
|
dc.identifier |
47849116709 |
|
dc.identifier.citation |
pagination=133-138;
journalVolume=139;
journalIssueNumber=2;
journalTitle=EUROPEAN JOURNAL OF OBSTETRICS GYNECOLOGY AND REPRODUCTIVE BIOLOGY; |
|
dc.identifier.uri |
http://repo.lib.semmelweis.hu//handle/123456789/6395 |
|
dc.identifier.uri |
doi:10.1016/j.ejogrb.2007.12.012 |
|
dc.description.abstract |
Objective: We have recently demonstrated that serum 70 kDa heat
shock protein (Hsp70) levels are increased in the syndrome of
hemolysis, elevated liver enzymes, and low platelet count (HELLP
syndrome). The aim of the present study was to investigate in an
independent, larger cohort of patients whether serum Hsp70
levels are related to laboratory markers of HELLP syndrome.
Study design: The study population included 14 patients with
HELLP syndrome. Serum Hsp70 levels were measured by enzyme-
linked immunosorbent assay. The relationship between serum Hsp70
levels and laboratory markers of hemolysis, hepatocellular
damage, renal insufficiency, inflammation or disseminated
intravascular coagulation (DIC), as well as platelet count was
investigated by calculating correlation coefficients,
standardized regression coefficients and by principal component
analysis. Results: Serum Hsp70 levels showed a very strong
correlation to the markers of hemolysis (plasma free hemoglobin
level, serum lactate dehydrogenase activity, and total bilirubin
level) and of hepatocellular injury (serum aminotransferase
activities), supported also by principal component analysis.
Furthermore, circulating Hsp70 concentration reflected the
severity of HELLP syndrome as expressed by the significant
inverse correlation to the lowest platelet count. By contrast,
there was no relationship between serum Hsp70 levels and markers
of inflammation, coagulation, fibrinolysis or renal
insufficiency. Conclusion: Elevated serum 70 kDa heat shock
protein level seems to reflect tissue damage (hemolysis and
hepatocellular injury) and disease severity in patients with
HELLP syndrome. However, further investigations are needed to
determine the clinical relevance of these findings. ? 2007
Elsevier Ireland Ltd. All rights reserved. |
|
dc.relation.ispartof |
urn:issn:0301-2115 |
|
dc.title |
Elevated serum 70 kDa heat shock protein level reflects tissue damage and disease severity in the syndrome of hemolysis, elevated liver enzymes, and low platelet count |
|
dc.type |
Journal Article |
|
dc.date.updated |
2018-09-02T10:32:24Z |
|
dc.language.rfc3066 |
en |
|
dc.identifier.mtmt |
1132244 |
|
dc.identifier.wos |
000259059400004 |
|
dc.identifier.pubmed |
18249485 |
|
dc.contributor.department |
SE/AOK/K/Aneszteziológiai és Intenzív Terápiás Klinika |
|
dc.contributor.department |
SE/AOK/K/III. Sz. Belgyógyászati Klinika |
|
dc.contributor.department |
SE/AOK/K/I. Sz. Szülészeti és Nőgyógyászati Klinika |
|
dc.contributor.institution |
Semmelweis Egyetem |
|
dc.mtmt.swordnote |
Madách Krisztina és Molvarec Attila megosztott első szerzők. |
|