Show simple item record Faay, MDM Czobor, Pál Sommer, IEC 2020-12-10T07:49:04Z 2020-12-10T07:49:04Z 2018
dc.identifier.citation journalVolume=43;journalIssueNumber=12;journalTitle=NEUROPSYCHOPHARMACOLOGY;pagerange=2340-2349;journalAbbreviatedTitle=NEUROPSYCHOPHARMACOL;
dc.identifier.uri doi:10.1038/s41386-018-0161-2
dc.description.abstract As violence against self and others is an important outcome in the treatment of patients with psychosis-spectrum disorders and hostility is an important indicator for violence, we set out to evaluate the effects of different types of antipsychotic agents in reducing hostility. We performed a systematic literature search, which provided 18 suitable randomized studies comparing typical to atypical antipsychotics for at least 4 weeks in patients with psychotic disorders. Results showed a small (0.26) but significant effect for atypical as compared to typical antipsychotics, with high heterogeneity, even though the mean dose of typical antipsychotics was higher. This effect size remained similar when separately analyzing sponsored and non-sponsored studies. When differentiating between high and low-dose studies, the high-dose group showed a significant difference between typical and atypical antipsychotics whereas the low-dose group did not. An analysis comparing clozapine to typical antipsychotics showed a moderate effect size (0.415), with low heterogeneity. These results are important for clinicians to help their shared decision making with patients when choosing maintenance treatment, as next to efficacy for psychosis and tolerability, safety for the patient and their environment is an important outcome.
dc.format.extent 2340-2349
dc.relation.ispartof urn:issn:0893-133X
dc.title Efficacy of typical and atypical antipsychotic medication on hostility in patients with psychosis-spectrum disorders: a review and meta-analysis 2019-01-03T09:52:50Z
dc.rights.holder NULL
dc.identifier.mtmt 3425641
dc.identifier.pubmed 30093698
dc.contributor.department SE/AOK/K/Pszichiátriai és Pszichoterápiás Klinika
dc.contributor.institution Semmelweis Egyetem

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