Kivonat:
Theuse of bone allografts is contraindicated in septic revision surgery due to the high risk of graft reinfection.Antibiotic release from
the graft may solve the problem and these combinations can theoretically be used for prevention or even therapy of infection.The
present study investigated whether amoxicillin, ciprofloxacin, and vancomycin alone or in combination with chitosan or alginate
are suitable for short-term or long-term bone coating. Human bone allografts were prepared from femoral head and lyophilized.
Antibiotic coating was achieved by incubating the grafts in antibiotic solution and freeze-drying again. Two biopolymers chitosan
and alginate were used for creating sustained-release implantable coatings and the drug release profile was characterized in vitro
by spectrophotometry. Using lyophilization with or without chitosan only resulted in short-term release that lasted up to 48 hours.
Alginate coating enabled a sustained release that lasted for 8 days with amoxicillin, 28 days with ciprofloxacin coating, and 50
days with vancomycin coating. Using only implantable biodegradable allograft and polymers, a sustained release of antibiotics was
achieved with ciprofloxacin and vancomycin for several weeks. Since the calculated daily release of the antibiotic was lower than
the recommended IV dose, the calcium alginate coated bone graft can support endoprosthesis revision surgery.
