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dc.contributor.author Nemeth, N
dc.contributor.author Putz, Zsuzsanna
dc.contributor.author Istenes, Iildikó
dc.contributor.author Körei, Anna Erzsébet
dc.contributor.author Vági, Orsolya
dc.contributor.author Kempler, Miklós
dc.contributor.author Gandhi, R
dc.contributor.author Jermendy, G
dc.contributor.author Tesfaye, S
dc.contributor.author Tabák, Ádám
dc.contributor.author Kempler, Péter
dc.date.accessioned 2020-02-21T10:19:59Z
dc.date.available 2020-02-21T10:19:59Z
dc.date.issued 2017
dc.identifier 85021408132
dc.identifier.citation journalVolume=27;journalIssueNumber=7;journalTitle=NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES;pagerange=609-614;journalAbbreviatedTitle=NUTR METAB CARDIOVAS;
dc.identifier.uri http://repo.lib.semmelweis.hu//handle/123456789/7268
dc.identifier.uri doi:10.1016/j.numecd.2017.05.001
dc.description.abstract BACKGROUND AND AIMS: To assess the risk factors for sensory nerve dysfunction in subjects with isolated impaired glucose tolerance (IGT). METHODS AND RESULTS: Seventy-two people with isolated IGT (WHO 1999 criteria) and 39 gender and age-matched healthy volunteers underwent detailed clinical and neurological assessment including quantitative sensory testing using the Neurometer device (current perception threshold measurement on four limbs at three different frequencies). Sensory nerve dysfunction was defined as at least two abnormalities on any frequencies on the upper or lower limbs. Sensory nerve dysfunction was more prevalent among subjects with IGT compared to controls (58.3 vs. 10.3%, OR: 11.23, 95%CI: 3.57-35.35). This association was not influenced by BMI, systolic and diastolic blood pressure, heart rate and autonomic neuropathy (multiple adjusted OR: 13.87, 95%CI: 3.18-60.58), but further adjustment for glycaemic measures abolished the association (OR: 1.58, 95%CI: 0.07-35.68). Assessing the components of glycaemic measures separately, the association between sensory nerve dysfunction and IGT was not affected by HbA1c (OR: 13.94, 95%CI: 1.84-105.5). It was, however, substantially attenuated by fasting plasma glucose (OR: 6.75, 95%CI: 1.33-34.27) while the significance was lost after adjustment for 120 min postload glucose level (OR: 3.76, 95%CI: 0.26-54.10). In the pooled population assessed, independent determinants of sensory nerve dysfunction were older age, 120 min glucose, higher height and cardiovascular autonomic neuropathy at near significance. CONCLUSIONS: Sensory nerve dysfunction amongst subjects with IGT was not explained by cardiovascular covariates, only by glycaemic measures. In addition to 120 min glucose, cardiovascular autonomic neuropathy at borderline significance, age, and height were the independent determinants of sensory nerve dysfunction.
dc.format.extent 609-614
dc.relation.ispartof urn:issn:0939-4753
dc.title Is there a connection between postprandial hyperglycemia and IGT related sensory nerve dysfunction?
dc.type Journal Article
dc.date.updated 2019-07-18T11:11:01Z
dc.language.rfc3066 en
dc.rights.holder NULL
dc.identifier.mtmt 3292205
dc.identifier.wos 000405503400003
dc.identifier.pubmed 28676377
dc.contributor.department SE/AOK/K/I. Sz. Belgyógyászati Klinika
dc.contributor.institution Semmelweis Egyetem


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