dc.contributor.author |
Faerch, K |
|
dc.contributor.author |
Witte, DR |
|
dc.contributor.author |
Brunner, EJ |
|
dc.contributor.author |
Kivimaki, M |
|
dc.contributor.author |
Tabák, Ádám |
|
dc.contributor.author |
Jorgensen, ME |
|
dc.contributor.author |
Ekelund, U |
|
dc.contributor.author |
Vistisen, D |
|
dc.date.accessioned |
2020-08-28T10:52:47Z |
|
dc.date.available |
2020-08-28T10:52:47Z |
|
dc.date.issued |
2017 |
|
dc.identifier.citation |
journalVolume=102;journalIssueNumber=10;journalTitle=JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM;pagerange=3712-3721;journalAbbreviatedTitle=J CLIN ENDOCR METAB; |
|
dc.identifier.uri |
http://repo.lib.semmelweis.hu//handle/123456789/7271 |
|
dc.identifier.uri |
doi:10.1210/jc.2017-00990 |
|
dc.description.abstract |
Context: The effects of physical activity (PA) on improvement of glycemia may differ between prediabetic individuals defined by oral glucose tolerance test vs glycated hemoglobin (HbA1c). Objective: We studied the association between PA and improvement of glycemia in individuals with prediabetes defined by glucose vs HbA1c criteria. Design, Setting, and Participants: From the Whitehall II study, 957 participants with prediabetes defined by isolated impaired fasting glucose (i-IFG), isolated impaired glucose tolerance (i-IGT), or both and 457 with prediabetes defined by HbA1c were included. Main Outcome Measures: The associations of PA with concomitant changes in glucose-related outcomes during 5 years of follow-up were analyzed. A recursive partitioning analysis was performed to study heterogeneity in the association between baseline PA and the probability of reversion to normoglycemia. Results: After 5 years of follow-up, 405 (42%) individuals with glucose-defined prediabetes reverted to normal glucose tolerance (NGT). A 5-year increase in moderate-to-vigorous-intensity PA was associated with improvements in insulin sensitivity and beta-cell function, but PA was not generally associated with reversion to NGT. Only among women >/=50 years with i-IFG or i-IGT, higher amounts of PA were associated with higher probability of reversion to NGT. In HbA1c-defined prediabetes, only 20 individuals (4.4%) reverted to normoglycemia, and PA was not associated with improvement in glycemic markers. Conclusions: PA may be particularly important for reversion to normoglycemia among older women with i-IFG or i-IGT. Individuals with prediabetes identified by HbA1c have a low probability of reversion to normoglycemia, and their changes in glycemia are not related to PA. |
|
dc.format.extent |
3712-3721 |
|
dc.relation.ispartof |
urn:issn:0021-972X |
|
dc.title |
Physical Activity and Improvement of Glycemia in Prediabetes by Different Diagnostic Criteria |
|
dc.type |
Journal Article |
|
dc.date.updated |
2019-07-18T11:16:17Z |
|
dc.language.rfc3066 |
en |
|
dc.rights.holder |
NULL |
|
dc.identifier.mtmt |
3302677 |
|
dc.identifier.wos |
000412450400011 |
|
dc.identifier.pubmed |
28973497 |
|
dc.contributor.department |
SE/AOK/K/I. Sz. Belgyógyászati Klinika |
|
dc.contributor.institution |
Semmelweis Egyetem |
|