Flow-chemistry enabled efficient synthesis of β-peptides: backbone topology vs. helix formation

dc.contributor.author	Nekkaa, Imane
dc.contributor.author	Bogdán, Dóra
dc.contributor.author	Gáti, Tamás
dc.contributor.author	Béni, Szabolcs
dc.contributor.author	Juhász, Tünde
dc.contributor.author	Palkó, Márta
dc.contributor.author	Paragi, Gábor
dc.contributor.author	Tóth, Gábor K.
dc.contributor.author	Fülöp, Ferenc
dc.contributor.author	Mándity, István M.
dc.date.accessioned	2019-08-26T15:50:34Z
dc.date.available	2019-08-26T15:50:34Z
dc.date.issued	2019
dc.identifier	85062612654
dc.identifier.citation	journalVolume=55;journalIssueNumber=21;journalTitle=CHEMICAL COMMUNICATIONS;pagerange=3061-3064;journalAbbreviatedTitle=CHEM COMMUN;
dc.identifier.uri	http://repo.lib.semmelweis.hu//handle/123456789/7434
dc.identifier.uri	doi:10.1039/C8CC10147G
dc.description.abstract	Enantiodiscriminative helix formation was observed for beta-peptide H14 helices. This observation is caused by the synperiplanar orientation of H-O atoms which is more unfavorable than those for H-H interaction. The 1,2 H-O interaction leads to the destruction of the helical structure. The introduction of a double C-C bond in the backbone rules out helix formation.
dc.format.extent	3061-3064
dc.title	Flow-chemistry enabled efficient synthesis of β-peptides: backbone topology vs. helix formation
dc.type	Journal Article
dc.date.updated	2019-08-10T08:05:12Z
dc.language.rfc3066	en
dc.rights.holder	NULL
dc.identifier.mtmt	30535263
dc.identifier.wos	000460731900033
dc.identifier.pubmed	30720807
dc.contributor.department	SE/GYTK/Farmakognózia Intézet
dc.contributor.department	SE/GYTK/Szerves Vegytani Intézet
dc.contributor.institution	Semmelweis Egyetem
dc.mtmt.swordnote	Funding Agency and Grant Number: Hungarian Research Foundation (OTKA) [K 115731]; Janos Bolyai Research Scholarship of the Hungarian Academy of Sciences; Bolyai + New National Excellence Program of the Ministry of Human Capacities [UNKP-18-4-SE-121]; [GINOP-2.3.2-15-2016-00014]; [GINOP-2.3.2-15-2016-00034] Funding text: We are grateful to the Hungarian Research Foundation (OTKA No. K 115731). The financial support of the GINOP-2.3.2-15-2016-00014 and GINOP-2.3.2-15-2016-00034 projects are acknowledged. This work was partially supported by the Janos Bolyai Research Scholarship of the Hungarian Academy of Sciences and by the Bolyai + New National Excellence Program (grant number: UNKP-18-4-SE-121) of the Ministry of Human Capacities (S. Beni).