Egyszerű nézet

dc.contributor.author Bohács, Anikó
dc.contributor.author Bikov, András
dc.contributor.author Ivancsó, István
dc.contributor.author Czaller, Ibolya
dc.contributor.author Böcskei, Renáta
dc.contributor.author Müller, Veronika
dc.contributor.author Rigó, János
dc.contributor.author Losonczy, György
dc.contributor.author Tamási, Lilla
dc.date.accessioned 2021-06-18T06:38:41Z
dc.date.available 2021-06-18T06:38:41Z
dc.date.issued 2016
dc.identifier 84961704500
dc.identifier.citation journalVolume=61;journalIssueNumber=4;journalTitle=RESPIRATORY CARE;pagerange=502-509;journalAbbreviatedTitle=RESP CARE;
dc.identifier.uri http://repo.lib.semmelweis.hu//handle/123456789/7796
dc.identifier.uri doi:10.4187/respcare.04339
dc.description.abstract BACKGROUND: Asthma often complicates pregnancy and represents a risk of serious pregnancy complications. The complement system contributes to asthma pathogenesis and is up-regulated in healthy gestation as well. The anaphylatoxin C5a has a major pro-inflammatory role, and the complement factor H is a main soluble regulator protein both in asthma and during pregnancy; however, peripheral levels of these complement factors and their relationship to disease control have not yet been evaluated in pregnant subjects with asthma. METHODS: The present study aimed to investigate circulating C5a and complement factor H levels in asthma (non-pregnant subjects with asthma; n = 19) and in pregnancy with asthma (pregnant subjects with asthma; n = 22), compared with healthy non-pregnant (n = 21) and healthy pregnant women (n = 13) and to test their relationship to clinical parameters of asthma (lung function, airway inflammation, and symptoms). RESULTS: Circulating C5a levels were higher in the pregnant asthma subject group compared with the healthy non-pregnant, healthy pregnant, and non-pregnant asthma groups: median 2.629 (interquartile range [IQR] 2.257-3.052) ng/mL versus 1.84 (IQR 1.576-2.563), 1.783 (IQR 0.6064-2.786), and 2.024 (IQR 1.232-2.615) ng/mL, respectively (P = .02 in all cases). C5a correlated negatively with FEV1 (r = -0.44, P = .039) and FVC values (r = -0.64, P = .001) in the pregnant asthma group and positively with fraction of exhaled nitric oxide levels in the non-pregnant asthma group (n = 12, r = 0.78, P = .004). Complement factor H levels were elevated in both the healthy pregnant and pregnant asthma subject groups compared with the healthy non-pregnant group (median 1,082 [IQR 734.9-1,224] and 910.7 [IQR 614.5-1076] mug/mL vs 559.7 [IQR 388.7-783.1] mug/mL, P = .002 and P = .004, respectively) but not in the pregnant asthma group compared with the non-pregnant asthma group (median 687.4 [IQR 441.6-947.6] mug/mL, P = .10). CONCLUSIONS: Asthma during pregnancy increases the circulating level of pro-inflammatory C5a, which is accompanied by impaired lung function and partly counteracted by the gestation-specific elevation of regulatory complement factor H level (detected in pregnancy both in healthy and subjects with asthma).
dc.format.extent 502-509
dc.relation.ispartof urn:issn:0020-1324
dc.title Relationship of Circulating C5a and Complement Factor H Levels With Disease Control in Pregnant Women With Asthma
dc.type Journal Article
dc.date.updated 2019-09-19T09:48:56Z
dc.language.rfc3066 en
dc.rights.holder NULL
dc.identifier.mtmt 3022379
dc.identifier.wos 000373240700016
dc.identifier.pubmed 26759418
dc.contributor.department SE/AOK/K/Pulmonológiai Klinika
dc.contributor.department SE/AOK/K/I. Sz. Szülészeti és Nőgyógyászati Klinika
dc.contributor.institution Semmelweis Egyetem


Kapcsolódó fájlok:

A fájl jelenleg csak egyetemi IP címről érhető el.

Megtekintés/Megnyitás

Ez a rekord az alábbi gyűjteményekben szerepel:

Egyszerű nézet