dc.contributor.author |
Eszes, Noémi |
|
dc.contributor.author |
Bikov, András |
|
dc.contributor.author |
Lázár, Zsófia |
|
dc.contributor.author |
Bohács, Anikó |
|
dc.contributor.author |
Müller, Veronika |
|
dc.contributor.author |
Stenczer, Balázs |
|
dc.contributor.author |
Rigó, János |
|
dc.contributor.author |
Losonczy, György |
|
dc.contributor.author |
Horváth, Ildikó |
|
dc.contributor.author |
Tamási, Lilla |
|
dc.date.accessioned |
2022-06-13T13:17:45Z |
|
dc.date.available |
2022-06-13T13:17:45Z |
|
dc.date.issued |
2013 |
|
dc.identifier |
84876492611 |
|
dc.identifier.citation |
journalVolume=92;journalIssueNumber=5;journalTitle=ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA;pagerange=591-597;journalAbbreviatedTitle=ACTA OBSTET GYN SCAN; |
|
dc.identifier.uri |
http://repo.lib.semmelweis.hu//handle/123456789/7916 |
|
dc.identifier.uri |
doi:10.1111/aogs.12094 |
|
dc.description.abstract |
OBJECTIVE: Asthma is a common chronic disease complicating pregnancy with a risk for perinatal complications. Control of airway inflammation in the asthmatic pregnancy improves pregnancy outcomes. Our aim was to evaluate pH of exhaled breath condensate (EBC), a non-invasive method for the assessment of asthmatic airway inflammation, in healthy and asthmatic pregnancies. DESIGN: Cross-sectional study. SETTING: Hungarian university clinics. POPULATION: Seventeen healthy pregnant women, 21 asthmatic pregnant women, 23 healthy non-pregnant women and 22 asthmatic non-pregnant women. METHODS: EBC samples were collected using a portable condenser, EBC pH was measured after argon deaeration. MAIN OUTCOME MEASURE: EBC pH. RESULTS: EBC pH (mean +/- SD) of healthy non-pregnant and asthmatic non-pregnant women was similar (7.75 +/- 0.27 vs. 7.54 +/- 0.57; p = 0.118), probably indicating an optimal control of airway inflammation in asthmatic women. On the other hand, EBC pH was higher in healthy pregnant women compared with healthy non-pregnant women (8.02 +/- 0.43 vs. 7.75 +/- 0.27; p = 0.017). Higher EBC pH accompanying healthy pregnancy was absent in asthmatic pregnant patients whose EBC pH was lower (7.65 +/- 0.38) than that of healthy pregnant women (p = 0.006), and it was similar to that in asthmatic and healthy non-pregnant women (p = 0.470 and p = 0.300, respectively). The EBC pH in asthmatic pregnant women correlated positively with birthweight (r = 0.49, p = 0.047) and negatively with forced vital capacity (r = 0.45, p = 0.039). EBC pH was not related to blood pH. CONCLUSIONS: EBC pH is higher in healthy pregnant women but not in asthmatic pregnant women compared with data from healthy non-pregnant women, indicating that oxidative inflammatory processes induced by asthma may compromise the regulatory mechanisms causing alkaline pH in the airways during pregnancy. |
|
dc.format.extent |
591-597 |
|
dc.relation.ispartof |
urn:issn:0001-6349 |
|
dc.title |
Changes in exhaled breath condensate pH in healthy and asthmatic pregnant women. |
|
dc.type |
Journal Article |
|
dc.date.updated |
2019-10-14T12:08:20Z |
|
dc.language.rfc3066 |
en |
|
dc.rights.holder |
NULL |
|
dc.identifier.mtmt |
2269939 |
|
dc.identifier.wos |
000319060200014 |
|
dc.identifier.pubmed |
23369006 |
|
dc.contributor.institution |
I. Sz. Szülészeti és Nőgyógyászati Klinika |
|
dc.contributor.institution |
Népegészségtani Intézet |
|
dc.contributor.institution |
MTA-SE Nephrológiai Kutatócsoport (2002-ig: MTA-SE Nephrológiai Kísérleti Kutató Laboratórium, 2007-től beolvadt az SE19-be) |
|
dc.contributor.institution |
Doktori Iskola |
|
dc.contributor.institution |
Szülészeti és Nőgyógyászati Klinikai Ismeretek Tanszék |
|
dc.contributor.institution |
Semmelweis Egyetem |
|
dc.contributor.institution |
Klinikai Kísérleti Kutató Intézet |
|
dc.contributor.institution |
Klinikai Kísérleti Kutató- és Humán Élettani Intézet |
|
dc.contributor.institution |
Pulmonológiai Klinika |
|