Show simple item record Sereg Márta Szappanos A Toke J Karlinger Kinga Feldman Karolina Kaszper E Varga I Gláz Edit Rácz Károly Tóth Miklós 2014-12-17T16:31:03Z 2014-12-17T16:31:03Z 2009
dc.identifier 64549126078
dc.identifier.citation pagination=647-655; journalVolume=160; journalIssueNumber=4; journalTitle=EUROPEAN JOURNAL OF ENDOCRINOLOGY;
dc.identifier.uri doi:10.1530/EJE-08-0707
dc.description.abstract Objective: Despite the increased prevalences of hypertension. type 2 diabetes mellitus (T2DM). hyperlipidemy, and obesity in patients with non-functioning adrenal adenomas (NFAAs), there is a paucity of data on long-term atherosclerotic morbidity as well as the long-term cardiovascular effects of adrenalectomy in these patients. Design, patients, and methods: This retrospective study includes the results or baseline and follow-up investigations of 125 patients (29 males and 96 females: mean age 60.1 years) with NFAAs referred for endocrine evaluation between 1990 and 2001. Of the 125 patients, 47 underwent unilateral adrenalectomy, while 78 patients were followed conservatively. These patients were reinvestigated after a mean follow-up time of 9.1 (5-16) years in 2006, with special emphasis on laboratory and other atherosclerotic risk factors (ARF), vascular events, and interventions. Results: The prevalences of hypertension, impaired glucose tolerance or T2DM, hyperlipidemy, and obesity were 82, 43, 58, and 50%, and 89, 58, 82, and 50% at baseline and follow-up, respectively None of the investigated ARF prevalences were different between patients treated and not treated with adrenalectomy, and between patients with and without subclinical Cushing's syndrome. The prevalences of angina pectoris, acute myocardial infarction, coronary and peripheral arterial interventions or cerebrovascular stroke did not differ significantly between patients treated and not treated with adrenalectomy Conclusion: Our study confirms previous investigations reporting markedly increased prevalences of various ARF in patients with NFAAs. Adrenalectomy performed in these patients failed to decrease the prevalence of ARF and atherosclerotic morbidity
dc.relation.ispartof urn:issn:0804-4643
dc.title Atherosclerotic risk factors and complications in patients with non-functioning adrenal adenomas treated with or without adrenalectomy: a long-term follow-up study
dc.type Journal Article 2014-12-13T18:01:14Z
dc.language.rfc3066 en
dc.identifier.mtmt 1367654
dc.identifier.wos 000272934300019
dc.identifier.pubmed 19174533
dc.contributor.department SE/ÁOK/K/II. Sz. Belgyógyászati Klinika
dc.contributor.department SE/ÁOK/K/Radiológiai és Onkoterápiás Klinika
dc.contributor.institution Semmelweis Egyetem

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