Low level of exosomal long non-coding RNA HOTTIP is a prognostic biomarker in colorectal cancer

dc.contributor.author	Oehme, F
dc.contributor.author	Krahl, S
dc.contributor.author	Győrffy, Balázs
dc.contributor.author	Muessle, B
dc.contributor.author	Rao, V
dc.contributor.author	Greif, H
dc.contributor.author	Ziegler, N
dc.contributor.author	Lin, K
dc.contributor.author	Thepkaysone, M-L
dc.contributor.author	Polster, H
dc.contributor.author	Tonn, T
dc.contributor.author	Schneider, M
dc.contributor.author	Weitz, J
dc.contributor.author	Baenke, F
dc.contributor.author	Kahlert, C
dc.date.accessioned	2021-09-15T11:35:41Z
dc.date.available	2021-09-15T11:35:41Z
dc.date.issued	2019
dc.identifier	85068585762
dc.identifier.citation	journalVolume=16;journalIssueNumber=10;journalTitle=RNA BIOLOGY;pagerange=1339-1345;journalAbbreviatedTitle=RNA BIOL;
dc.identifier.uri	http://repo.lib.semmelweis.hu//handle/123456789/8035
dc.identifier.uri	doi:10.1080/15476286.2019.1637697
dc.description.abstract	Molecular risk stratification of colorectal cancer can improve patient outcome. A panel of lncRNAs (H19, HOTTIP, HULC and MALAT1) derived from serum exosomes of patients with non-metastatic CRC and healthy donors was analyzed. Exosomes from healthy donors carried significantly more H19, HULC and HOTTIP transcripts in comparison to CRC patients. Correlation analysis between lncRNAs and clinical data revealed a statistical significance between low levels of exosomal HOTTIP and poor overall survival. This was confirmed by multivariate analysis that HOTTIP is an independent prognostic marker for overall survival (HR: 4.5, CI: 1.69–11.98, p = 0.0027). Here, HOTTIP poses to be a valid biomarker for patients with a CRC to predict post-surgical survival time. © 2019, © 2019 Informa UK Limited, trading as Taylor & Francis Group.
dc.format.extent	1339-1345
dc.relation.ispartof	urn:issn:1547-6286
dc.title	Low level of exosomal long non-coding RNA HOTTIP is a prognostic biomarker in colorectal cancer
dc.type	Journal Article
dc.date.updated	2019-11-28T13:40:00Z
dc.language.rfc3066	en
dc.rights.holder	NULL
dc.identifier.mtmt	30816152
dc.identifier.wos	000474688500001
dc.identifier.pubmed	31251124
dc.contributor.department	SE/AOK/K/II. Sz. Gyermekgyógyászati Klinika
dc.contributor.institution	Semmelweis Egyetem