dc.contributor.author |
Veres Gábor |
|
dc.contributor.author |
Radovits Tamás |
|
dc.contributor.author |
Seres Leila |
|
dc.contributor.author |
Horkay Ferenc |
|
dc.contributor.author |
Karck M |
|
dc.contributor.author |
Szabó Gábor Balázs |
|
dc.date.accessioned |
2014-12-18T08:40:58Z |
|
dc.date.available |
2014-12-18T08:40:58Z |
|
dc.date.issued |
2010 |
|
dc.identifier |
78049482925 |
|
dc.identifier.citation |
pagination=106;
journalVolume=5;
journalTitle=JOURNAL OF CARDIOTHORACIC SURGERY; |
|
dc.identifier.uri |
http://repo.lib.semmelweis.hu//handle/123456789/828 |
|
dc.identifier.uri |
doi:10.1186/1749-8090-5-106 |
|
dc.description.abstract |
OBJECTIVE: Inosine, a break-down product of adenosine has been recently shown to exert inodilatory and anti-inflammatory properties. Furthermore inosine might be a key substrate of pharmacological post-conditioning. In the present pre-clinical study, we investigated the effects of inosine on cardiac function during reperfusion in an experimental model of cardioplegic arrest and extracorporal circulation. METHODS: Twelve anesthetized dogs underwent hypothermic cardiopulmonary bypass. After 60 minutes of hypothermic cardiac arrest, reperfusion was started after application of either saline vehicle (control, n = 6), or inosine (100 mg/kg, n = 6). Left ventricular end-systolic pressure volume relationship (ESPVR) was measured by a combined pressure-volume-conductance catheter at baseline and after 60 minutes of reperfusion. Left anterior descendent coronary blood flow (CBF), endothelium-dependent vasodilatation to acetylcholine (ACh) and endothelium-independent vasodilatation to sodium nitroprusside (SNP) were also determined. RESULTS: The administration of inosine led to a significantly better recovery (given as percent of baseline) of ESPVR 90 +/- 9% vs. 46 +/- 6%, p < 0.05. CBF and was also significantly higher in the inosine group (56 +/- 8 vs. 23 +/- 4, ml/min, p < 0.05). While the vasodilatatory response to SNP was similar in both groups, ACh resulted in a significantly higher increase in CBF (58 +/- 6% vs. 25 +/- 5%, p < 0.05) in the inosine group. CONCLUSIONS: Application of inosine improves myocardial and endothelial function after cardiopulmonary bypass with hypothermic cardiac arrest. |
|
dc.relation.ispartof |
urn:issn:1749-8090 |
|
dc.title |
Effects of inosine on reperfusion injury after cardiopulmonary bypass |
|
dc.type |
Journal Article |
|
dc.date.updated |
2014-12-17T18:36:00Z |
|
dc.language.rfc3066 |
en |
|
dc.identifier.mtmt |
1510105 |
|
dc.identifier.wos |
000284552200001 |
|
dc.identifier.pubmed |
21059208 |
|
dc.contributor.department |
SE/ÁOK/K/Kardiológiai Központ, Kardiológia Tanszék (névváltozás: 2012-től Kardiológiai Tanszék-Kardiológiai Központ) |
|
dc.contributor.department |
SE/ÁOK/K/Szívsebészeti Klinika-névváltozás: 2012- Szívsebészeti Tanszék |
|
dc.contributor.institution |
Semmelweis Egyetem |
|