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dc.contributor.author Bánhidy Ferenc
dc.contributor.author Dakhlaoui A
dc.contributor.author Puho EH
dc.contributor.author Czeizel Endre
dc.date.accessioned 2014-12-22T09:24:25Z
dc.date.available 2014-12-22T09:24:25Z
dc.date.issued 2011
dc.identifier 79956207502
dc.identifier.citation pagination=80-86; journalVolume=51; journalIssueNumber=2; journalTitle=CONGENITAL ANOMALIES;
dc.identifier.uri http://repo.lib.semmelweis.hu//handle/123456789/831
dc.identifier.uri doi:10.1111/j.1741-4520.2010.00302.x
dc.description.abstract The objective of the present study was to estimate the preventive effect of folic acid for structural birth defects (i.e. congenital abnormalities [CAs]) in the offspring of pregnant women with diabetes mellitus type 1 (DM-1). The occurrence of medically recorded DM-1 in pregnant women who had malformed fetuses/newborns (cases) and delivered healthy babies (controls) with or without folic acid supplementation was compared in the population-based Hungarian Case-Control Surveillance System of Congenital Abnormalities. The case group included 22,843 offspring, and there were 79 (0.35%) pregnant women with DM-1, while the control group comprised of 38,151 newborns, and 88 (0.23%) had mothers with DM-1. Case mothers with DM-1 associated with a higher risk of total rate of CAs in their offspring (OR with 95% CI: 1.5, 1.1-2.0) compared to the total rate of CAs in the offspring of non-diabetic case mothers. This higher risk can be explained by four specific types/groups of CAs: isolated renal a/dysgenesis; obstructive CA of the urinary tract; cardiovascular CAs; and multiple CAs, namely caudal dysplasia sequence. However, there was no higher rate of total CAs in the children of pregnant women with DM-1 after folic acid supplementation; in addition, neural-tube defect and renal a/dysgenesis did not occur. However, this benefit cannot be explained by the CA reduction effect of folic acid during the critical period of major CAs. In conclusion, there was a certain reduction in maternal teratogenic effect of DM-1 after folic acid supplementation during pregnancy, but the explanation of this effect requires further study.
dc.relation.ispartof urn:issn:0914-3505
dc.title Is there a reduction of congenital abnormalities in the offspring of diabetic pregnant women after folic acid supplementation? A population-based case-control study
dc.type Journal Article
dc.date.updated 2014-12-18T09:30:24Z
dc.language.rfc3066 en
dc.identifier.mtmt 1740306
dc.identifier.wos 000290816200005
dc.identifier.pubmed 21039913
dc.contributor.department SE/ÁOK/K/II. Sz. Szülészeti és Nőgyógyászati Klinika
dc.contributor.institution Semmelweis Egyetem


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