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dc.contributor.author Szijártó Attila
dc.contributor.author Turóczi Zsolt
dc.contributor.author Szabó József
dc.contributor.author Kaliszky Péter
dc.contributor.author Gyurkovics Endre
dc.contributor.author Arányi Péter
dc.contributor.author Regáli László
dc.contributor.author Harsányi László
dc.contributor.author Lotz Gábor
dc.date.accessioned 2015-01-07T15:13:33Z
dc.date.available 2015-01-07T15:13:33Z
dc.date.issued 2013
dc.identifier.citation pagination=493-500; journalVolume=22; journalIssueNumber=6; journalTitle=CARDIOVASCULAR PATHOLOGY;
dc.identifier.uri http://repo.lib.semmelweis.hu//handle/123456789/923
dc.identifier.uri doi:10.1016/j.carpath.2013.02.006
dc.description.abstract The most severe complication of ischemia-reperfusion injury following lower limb arterial surgery is reperfusion syndrome. Therefore, our aim was to describe the extent of muscle damage and the reperfusion syndrome-related remote organ lesions in detail, through a well-documented case of long-lasting infrarenal aorta thrombosis. After urgent revascularization, several clinical signs of multiple organ dysfunction were detectable, including the circulatory, urinary, respiratory, gastrointestinal, and hemostatic systems. Upon histological examination, intraoperative muscle biopsy showed severe muscle damage. Muscle fiber viability was assessed with a special nitroblue tetrazolium staining-based viability test developed by our team; the obtained results indicated significant degree of muscle damage before this was confirmed by conventional histological methods. Thorough postmortem examination confirmed the presence of remote organ damage. The pathological findings included acute tubular necrosis, myocardial and jejunal infarctions, ischemic pancreatitis, and diffuse alveolar damage with hyaline membrane formation in the lungs and focal centrilobular liver necrosis. By using special staining techniques, the presence of myoglobin and lipofuscin deposits was confirmed in the kidney samples. In this paper, we present a patient who developed all major complications following long-lasting arterial occlusion. We also introduce a novel method to assess the degree of ischemic injury, which may be suitable in the near future for the rapid detection of irreversible muscle injury. Therefore, the mortality of the disease might be reduced.
dc.relation.ispartof urn:issn:1054-8807
dc.title Rapidly progressing fatal reperfusion syndrome caused by acute critical ischemia of the lower limb
dc.type Journal Article
dc.date.updated 2015-01-06T13:33:44Z
dc.language.rfc3066 en
dc.identifier.mtmt 2402019
dc.identifier.wos 000327153100012
dc.identifier.pubmed 23850181
dc.contributor.department SE/ÁOK/I/II. Sz. Patológiai Intézet
dc.contributor.department SE/ÁOK/K/I. Sz. Sebészeti Klinika
dc.contributor.institution Semmelweis Egyetem


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