Donnelly PM; Kolossváry, Márton József; Karády, Júlia; Ball PA; Kelly S; Fitzsimons D; Spence MS;; Celeng, Csilla; Horváth, Tamás; Szilveszter, Bálint; van Es HW; Swaans MJ; Merkely, Béla Péter; Maurovich-Horvat, Pál(2018)
Fractional flow reserve (FFR) derived from coronary computed tomography angiography (CTA) is a new technique for the diagnosis of ischemic coronary artery stenoses. The aim of this prospective study was to evaluate the ...
We recently introduced Drug Profile Matching (DPM), a novel affinity fingerprinting-based in silico drug repositioning approach. DPM is able to quantitatively predict the complete effect profiles of compounds via probability ...
Fülöp András; Turóczi Zsolt; Garbaisz Dávid; Harsányi László; Szijártó Attila(2013)
Massive blood loss leading to hypovolemic shock is still a life-threatening situation. Recently, a great number of investigations have been conducted in order to understand the pathophysiological and immunological changes ...
BACKGROUND: Electronic noses are composites of nanosensor arrays. Numerous studies showed their potential to detect lung cancer from breath samples by analysing exhaled volatile compound pattern ("breathprint"). Expiratory ...
BACKGROUND: Strategies for the involvement of primary care in the management of patients with presumed or diagnosed dementia are heterogeneous across Europe. We wanted to explore attitudes of primary care physicians (PCPs) ...
Fiona M Harris; Margaret Maxwell; Rory O’Connor; James C Coyne; Ella Arensman; Claire Coffey; Nicole Koburge; Ricardo Gusmão; Susana Costa; Székely, András; Cserháti, Zoltán; David McDaid; Chantal van Audenhove; Ulrich Hegerl(2016)
BACKGROUND:
The Medical Research Council (MRC) Framework for complex interventions highlights the need to explore interactions between components of complex interventions, but this has not yet been fully explored within ...
The analysis of highly polar (often charged) compounds which lack a strong UV absorbing chromophore is really challenging. Despite the numerous analytical methods published, the demand for a simple, robust and cheap technique ...
Ádori, Csaba; Barde S; Vas, Szilvia; Ebner K; Su J; Bagdy, György(2016)
Neuropeptide S (NPS) is a regulatory peptide expressed by limited number of neurons in the brainstem. The simultaneous anxiolytic and arousal-promoting effect of NPS suggests an involvement in mood control and vigilance, ...
Purpose: By catalyzing cGMP hydrolysis, phosphodiesterase (PDE) 5 is a critical regulator of its concentration and effects in different (patho)physiologic processes, including cancers. As PDE5 is a known druggable target, ...
Expression of heat shock proteins (HSPs) is of prognostic
significance in several tumor types. HSP expression levels were
determined in medulloblastomas and tested whether HSPs
expression was associated with prognostic ...
Patel H; Abduljabbar R; Lai CF; Periyasamy M; Harrod A; Gemma C; Steel J; Patel N; Busonero C; Jerjees D; Remenyi J; Smith S; Gomm JJ; Magnani L; Győrffy, Balázs; Jones JL; Fuller-Pace FV; Shousha S; Buluwela L; Rakha EA; Ellis IO; Coombes RC; Ali S(2016)
PURPOSE: CDK-activation kinase (CAK) is required for the regulation of the cell-cycle and is a trimeric complex consisting of Cyclin Dependent Kinase 7 (CDK7), Cyclin H and the accessory protein, MAT1. CDK7 also plays a ...