tallózása szerző szerint "Csonka, Csaba"

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  • Adverse Effects on beta-Adrenergic Receptor Coupling: Ischemic Postconditioning Failed to Preserve Long-Term Cardiac Function 
    Schreckenberg R; Bencsik, Péter; Weber M; Abdallah Y; Csonka, Csaba; Gömöri, Kamilla; Kiss, Krisztina; Pálóczi, János; Pipis J; Sárközy, Márta; Ferdinandy, Péter; Schulz R; Schluter KD (2017)
    BACKGROUND: Ischemic preconditioning (IPC) and ischemic postconditioning (IPoC) are currently among the most efficient strategies protecting the heart against ischemia/reperfusion injury. However, the effect of IPC and ...
  • Anti-diabetic effect of a preparation of vitamins, minerals and trace elements in diabetic rats: a gender difference 
    Sárközy, Márta; Fekete, Veronika; Szűcs, Gergő; Török, Szilvia; Szűcs, Csilla; Barkányi, Judit; Varga, Zoltán; Földesi, Imre; Csonka, Csaba; Kónya, Csaba; Csont, Tamás Bálint; Ferdinandy, Péter (2014)
    BACKGROUND: Although multivitamin products are widely used as dietary supplements to maintain health or as special medical food in certain diseases, the effects of these products were not investigated in diabetes mellitus, ...
  • Cardioprotection by Farnesol: Role of the Mevalonate Pathway 
    Szűcs, Gergő; Murlasits, Zsolt; Török, Szilvia; Kocsis-Fodor, Gabriella; Pálóczi, János; Görbe, Anikó; Csont, Tamás Bálint; Csonka, Csaba; Ferdinandy, Péter (2013)
    Purpose: Farnesol is a key metabolite of the mevalonate pathway and known as an antioxidant. We examined whether farnesol treatment protects the ischemic heart. Methods: Male Wistar rats were treated orally with 0.2, 1, ...
  • Cholesterol-enriched diet inhibits cardioprotection by ATP-sensitive K+ channel activators cromakalim and diazoxide 
    Csonka, Csaba; Kupai, Krisztina; Bencsik, Péter; Görbe, Anikó; Pálóczi, János; Zvara, Ágnes; Puskás, László; Csont, Tamás Bálint; Ferdinandy, Péter (2014)
    It has been previously shown that hyperlipidemia interferes with cardioprotective mechanisms. Here we investigated the interaction of hyperlipidemia with cardioprotection induced by pharmacological activators of ATP-sensitive ...
  • Development of Matrix Metalloproteinase-2 Inhibitors for Cardioprotection 
    Bencsik, Péter; Kupai, Krisztina; Görbe, Anikó; Kenyeres, Éva; Varga, Zoltán; Pálóczi, János; Gáspár, Renáta; Kovács László; Lutz Weber; Takács Ferenc; Hajdú, István; Fabó Gabriella; Cseh, Sándor; Barna, László; Csont, Tamás; Csonka, Csaba; Dormán, György; Ferdinandy, Péter (2018)
    The objective of our present study is to develop novel inhibitors for MMP-2 for acute cardioprotection. In a series of pilot studies, novel substituted carboxylic acid derivatives were synthesized based on imidazole and ...
  • Effect of a multivitamin preparation supplemented with phytosterol on serum lipids and infarct size in rats fed with normal and high cholesterol diet 
    Csont, Tamás Bálint; Sárközy, Márta; Szűcs, Gergő; Szűcs, Csilla; Barkányi, Judit; Bencsik, Péter; Gáspár, Renáta; Földesi, Imre; Csonka, Csaba; Kónya, Csaba; Ferdinandy, Péter (2013)
    BACKGROUND: Although complex multivitamin products are widely used as dietary supplements to maintain health or as special medical food in certain diseases, the effects of these products were not investigated in hyperlipidemia ...
  • Hypercholesterolemia downregulates autophagy in the rat heart 
    Giricz, Zoltán; Koncsos, Gábor; Tomáš Rajtík; Varga, Zoltán; Baranyai, Tamás; Csonka, Csaba; Adrián Szobi; Adriana Adameová; Roberta A Gottlieb; Ferdinandy, Péter (2017)
    Background: We have previously shown that efficiency of ischemic conditioning is diminished in hypercholesterolemia and that autophagy is necessary for cardioprotection. However, it is unknown whether isolated hypercholesterolemia ...
  • Interaction between Connexin 43 and nitric oxide synthase in mice heart mitochondria 
    Kirca M; Kleinbongard P; Soetkamp D; Heger J; Csonka, Csaba; Ferdinandy, Péter; Schulz R (2015)
    Connexin 43 (Cx43), which is highly expressed in the heart and especially in cardiomyocytes, interferes with the expression of nitric oxide synthase (NOS) isoforms. Conversely, Cx43 gene expression is down-regulated by ...
  • Ischemic postconditioning alters the gene expression pattern of the ischemic heart 
    Csonka, Csaba; Szűcs, Gergő; Varga-Orvos, Zoltán; Bencsik, Péter; Csont, Tamás Bálint; Zvara, Ágnes; Puskás, László; Ferdinandy, Péter (2014)
    To profile changes in gene expression in response to ischemic postconditioning, isolated rat hearts were subjected to 30 min of regional ischemia followed by 120 min of reperfusion with or without postconditioning. At the ...
  • Isolated hypercholesterolemia leads to steatosis in the liver without affecting the pancreas 
    Csonka, Csaba; Baranyai, Tamás; Tiszlavicz, László; Fébel, Hedvig; Szűcs, Gergő; Varga, Zoltán; Sárközy, Márta; Puskás, László; Antal, Otilia Tamara; Siska, Andrea; Földesi, Imre; Ferdinandy, Péter; Czakó, László; Csont, Tamás Bálint (2017)
  • Measurement of NO in biological samples 
    Csonka, Csaba; Páli, Tibor; Bencsik, Péter; Görbe, Anikó; Ferdinandy, Péter; Csont, Tamás Bálint (2015)
  • Mechanism and consequences of the shift in cardiac arginine metabolism following ischaemia and reperfusion in rats 
    Schreckenberg R; Weber P; Cabrera-Fuentes HA; Steinert I; Preissner KT; Bencsik, Péter; Sárközy, Márta; Csonka, Csaba; Ferdinandy, Péter; Schulz R; Schluter KD (2015)
    Cardiac ischaemia and reperfusion leads to irreversible injury and subsequent tissue remodelling. Initial reperfusion seems to shift arginine metabolism from nitric oxide (NO) to polyamine formation. This may limit functional ...
  • Metabolic syndrome influences cardiac gene expression pattern at the transcript level in male ZDF rats 
    Sárközy, Márta; Zvara, Ágnes; Gyemant N; Fekete V; Kocsis-Fodor, Gabriella; Pipis, Judit; Szűcs, Gergő; Csonka, Csaba; Puskás, László; Ferdinandy, Péter; Csont, Tamás Bálint (2013)
    ABSTRACT: BACKGROUND: Metabolic syndrome (coexisting visceral obesity, dyslipidemia, hyperglycemia, and hypertension) is a prominent risk factor for cardiovascular morbidity and mortality, however, its effect on cardiac ...
  • MicroRNA-25-dependent up-regulation of NADPH oxidase 4 (NOX4) mediates hypercholesterolemia-induced oxidative/nitrative stress and subsequent dysfunction in the heart 
    Varga, Zoltán; Kupai, Krisztina; Szűcs, Gergő; Gáspár, Renáta; Pálóczi, János; Faragó, Nóra; Zvara, Ágnes; Puskás, László; Rázga, Zsolt; Tiszlavicz, László; Bencsik, Péter; Görbe, Anikó; Csonka, Csaba; Ferdinandy, Péter; Csont, Tamás Bálint (2013)
    Diet-induced hypercholesterolemia leads to oxidative/nitrative stress and subsequent myocardial dysfunction. However, the regulatory role of microRNAs in this phenomenon is unknown. We aimed to investigate, whether ...
  • MicroRNAs associated with ischemia/reperfusion injury and cardioprotection by ischemic pre- and postconditioning: ProtectomiRs 
    Varga, Zoltán; Zvara, Ágnes; Faragó, Nóra; Kocsis-Fodor, Gabriella; Pipicz, Márton; Gáspár, Renáta; Bencsik, Péter; Görbe, Anikó; Csonka, Csaba; Puskás, László; Thum T; Csont, Tamás Bálint; Ferdinandy, Péter (2014)
    We aimed to characterize early changes in microRNA expression in acute cardioprotection by ischemic pre- and postconditioning in rat hearts. Hearts isolated from male Wistar rats were subjected to i) time-matched non-ischemic ...
  • Moderate inhibition of myocardial matrix metalloproteinase-2 by ilomastat is cardioprotective 
    Bencsik, Péter; Pálóczi, János; Kocsis-Fodor, Gabriella; Pipis, Judit; Belecz, István; Varga, Zoltán; Csonka, Csaba; Görbe, Anikó; Csont, Tamás Bálint; Ferdinandy, Péter (2014)
    Pharmacological inhibition of matrix metalloproteinase-2 (MMP-2) is a promising target for acute cardioprotection against ischemia/reperfusion injury. Therefore, here we investigated if the MMP inhibitor ilomastat administered ...
  • Nitric oxide synthetic pathway and cGMP levels are altered in red blood cells from end-stage renal disease patients 
    Di Pietro, N; Giardinelli, A; Sirolli, V; Riganti, C; Di Tomo, P; Gazzano, E; Di Silvestre, S; Panknin, C; Cortese-Krott, MM; Csonka, Csaba; Kelm, M; Ferdinandy, Péter; Bonomini, M; Pandolfi, A (2016)
    Red blood cells (RBCs) enzymatically produce nitric oxide (NO) by a functional RBC-nitric oxide synthase (RBC-NOS). NO is a vascular key regulatory molecule. In RBCs its generation is complex and influenced by several ...
  • Novel, selective EPO receptor ligands lacking erythropoietic activity reduce infarct size in acute myocardial infarction in rats 
    Kiss, Krisztina; Csonka, Csaba; Pálóczi, János; Pipis, Judit; Görbe, Anikó; Kocsis-Fodor, Gabriella; Murlasits Z; Sárközy, Márta; Szűcs, Gergő; Holmes CP; Pan Y; Bhandari A; Csont, Tamás Bálint; Shamloo M; Woodburn KW; Ferdinandy, Péter; Bencsik, Péter (2016)
    Erythropoietin (EPO) has been shown to protect the heart against acute myocardial infarction in pre-clinical studies, however, EPO failed to reduce infarct size in clinical trials and showed significant safety problems. ...
  • Specific Mechanisms underlying Right Heart Failure 
    Schreckenberg, R; da Costa, Rebelo M; Deten, A; Weber, M; Rohrbach, S; Pipicz, Márton; Csonka, Csaba; Ferdinandy, Péter; Schulz, R; Schluter, KD (2015)
    AIMS: Research into right ventricular (RV) physiology and identification of pathomechanisms underlying RV failure have been neglected for many years because function of the RV is often considered to be less important for ...
  • The effect of a preparation of minerals, vitamins and trace elements on the cardiac gene expression pattern in male diabetic rats 
    Sárközy, Márta; Szűcs, Gergő; Pipicz, Márton; Zvara, Ágnes; Eder K; Fekete V; Szucs C; Barkanyi J; Csonka, Csaba; Puskás, László; Konya C; Ferdinandy, Péter; Csont, Tamás Bálint (2015)
    BACKGROUND: Diabetic patients have an increased risk of developing cardiovascular diseases, which are the leading cause of death in developed countries. Although multivitamin products are widely used as dietary supplements, ...