tallózása szerző szerint "Gáspár, Renáta"

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Activation of PPARbeta/delta protects cardiac myocytes from oxidative stress-induced apoptosis by suppressing generation of reactive oxygen/nitrogen species and expression of matrix metalloproteinases

Barlaka E; Görbe, Anikó; Gáspár, Renáta; Pálóczi, János; Ferdinandy, Péter; Lazou A (2015)

Heart failure still remains one of the leading causes of morbidity and mortality worldwide. A major contributing factor is reactive oxygen/nitrogen species (RONS) overproduction which is associated with cardiac remodeling ...
Development of Matrix Metalloproteinase-2 Inhibitors for Cardioprotection

Bencsik, Péter; Kupai, Krisztina; Görbe, Anikó; Kenyeres, Éva; Varga, Zoltán; Pálóczi, János; Gáspár, Renáta; Kovács László; Lutz Weber; Takács Ferenc; Hajdú, István; Fabó Gabriella; Cseh, Sándor; Barna, László; Csont, Tamás; Csonka, Csaba; Dormán, György; Ferdinandy, Péter (2018)

The objective of our present study is to develop novel inhibitors for MMP-2 for acute cardioprotection. In a series of pilot studies, novel substituted carboxylic acid derivatives were synthesized based on imidazole and ...
Effect of a multivitamin preparation supplemented with phytosterol on serum lipids and infarct size in rats fed with normal and high cholesterol diet

Csont, Tamás Bálint; Sárközy, Márta; Szűcs, Gergő; Szűcs, Csilla; Barkányi, Judit; Bencsik, Péter; Gáspár, Renáta; Földesi, Imre; Csonka, Csaba; Kónya, Csaba; Ferdinandy, Péter (2013)

BACKGROUND: Although complex multivitamin products are widely used as dietary supplements to maintain health or as special medical food in certain diseases, the effects of these products were not investigated in hyperlipidemia ...
JDP2 overexpression provokes cardiac dysfunction in mice

Heger J; Bornbaum J; Wurfel A; Hill C; Brockmann N; Gáspár, Renáta; Pálóczi, János; Varga, Zoltán; Sárközy, Márta; Bencsik, Péter; Csont, Tamás Bálint; Török, Szilvia; Kojonazarov B; Schermuly RT; Bongler K; Parahuleva M; Ferdinandy, Péter; Schulz R; Euler G (2018)

The transcriptional regulator JDP2 (Jun dimerization protein 2) has been identified as a prognostic marker for patients to develop heart failure after myocardial infarction. We now performed in vivo studies on JDP2-overexpressing ...
L-Alpha-glycerylphosphorylcholine can be cytoprotective or cytotoxic in neonatal rat cardiac myocytes

Tuboly, Eszter; Gáspár, Renáta; Ibor, Miguel Olias; Gömöri, Kamilla; Kiss, Bernadett; Strifler, Gerda; Hartmann, Petra; Ferdinandy, Péter; Bartekova, Monika; Boros, Mihály; Görbe, Anikó (2019)

L-Alpha-glycerylphosphorylcholine (GPC) is a widely used food supplement. GPC has been shown to exert beneficial effects in several organs; however, the cardiac effects of GPC have yet to be investigated. The aim of the ...
MicroRNA-25-dependent up-regulation of NADPH oxidase 4 (NOX4) mediates hypercholesterolemia-induced oxidative/nitrative stress and subsequent dysfunction in the heart

Varga, Zoltán; Kupai, Krisztina; Szűcs, Gergő; Gáspár, Renáta; Pálóczi, János; Faragó, Nóra; Zvara, Ágnes; Puskás, László; Rázga, Zsolt; Tiszlavicz, László; Bencsik, Péter; Görbe, Anikó; Csonka, Csaba; Ferdinandy, Péter; Csont, Tamás Bálint (2013)

Diet-induced hypercholesterolemia leads to oxidative/nitrative stress and subsequent myocardial dysfunction. However, the regulatory role of microRNAs in this phenomenon is unknown. We aimed to investigate, whether ...
MicroRNAs associated with ischemia/reperfusion injury and cardioprotection by ischemic pre- and postconditioning: ProtectomiRs

Varga, Zoltán; Zvara, Ágnes; Faragó, Nóra; Kocsis-Fodor, Gabriella; Pipicz, Márton; Gáspár, Renáta; Bencsik, Péter; Görbe, Anikó; Csonka, Csaba; Puskás, László; Thum T; Csont, Tamás Bálint; Ferdinandy, Péter (2014)

We aimed to characterize early changes in microRNA expression in acute cardioprotection by ischemic pre- and postconditioning in rat hearts. Hearts isolated from male Wistar rats were subjected to i) time-matched non-ischemic ...
Protection of neonatal rat cardiac myocytes against radiation-induced damage with agonists of growth hormone-releasing hormone

Kiscsatári, Laura; Varga, Zoltán; Schally AV; Gáspár, Renáta; Nagy, Csilla Terézia; Giricz, Zoltán; Ferdinandy, Péter; Fábián, Gabriella; Kahán, Zsuzsanna; Görbe, Anikó (2016)

Despite the great clinical significance of radiation-induced cardiac damage, experimental investigation of its mechanisms is an unmet need in medicine. Beneficial effects of growth hormone-releasing hormone (GHRH) agonists ...
Transcriptomic alterations in the heart of non-obese type 2 diabetic Goto-Kakizaki rats

Sárközy, Márta; Szűcs, Gergő; Fekete V; Pipicz, Márton; Eder K; Gáspár, Renáta; Sója, Andrea; Pipis, Judit; Ferdinandy, Péter; Csonka, Csaba; Csont, Tamás Bálint (2016)

BACKGROUND: There is a spectacular rise in the global prevalence of type 2 diabetes mellitus (T2DM) due to the worldwide obesity epidemic. However, a significant proportion of T2DM patients are non-obese and they also have ...

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tallózása szerző szerint "Gáspár, Renáta"

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