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Bisulfite-Based DNA Methylation Analysis from Recent and Archived Formalin-Fixed, Paraffin Embedded Colorectal Tissue Samples.

Kalmár, Alexandra; Péterfia, Bálint; Hollósi, Péter; Wichmann, Barnabás; Bodor, András; Patai, Árpád V; Schöller, Andrea; Krenács, Tibor; Tulassay, Zsolt; Molnár, Béla (2015)

We aimed to test the applicability of formalin-fixed and paraffin-embedded (FFPE) tissue samples for gene specific DNA methylation analysis after using two commercially available DNA isolation kits. Genomic DNA was isolated ...
Comprehensive DNA Methylation Analysis Reveals a Common Ten-Gene Methylation Signature in Colorectal Adenomas and Carcinomas

Patai, Árpád V; Valcz, Gábor; Hollósi, Péter; Kalmár, Alexandra; Péterfia, Bálint; Patai, Árpád; Wichmann, Barnabás; Spisak S; Barták, Barbara Kinga; Leiszter, Katalin; Tóth, Kinga; Sipos, Ferenc; Kovalszky, Ilona; Péter, Zoltán; Miheller, Pál; Tulassay, Zsolt; Molnár, Béla (2015)

Microarray analysis of promoter hypermethylation provides insight into the role and extent of DNA methylation in the development of colorectal cancer (CRC) and may be co-monitored with the appearance of driver mutations. ...
DNA hypermethylation and decreased mRNA expression of MAL, PRIMA1, PTGDR and SFRP1 in colorectal adenoma and cancer

Kalmár, Alexandra; Péterfia, Bálint; Hollósi, Péter; Udvardyné Galamb, Orsolya; Spisák, Sándor; Wichmann, Barnabás; Bodor, András; Tóth, Kinga; Patai, Árpád V; Valcz, Gábor; Nagy, Zsófia; Vivien Kubák; Tulassay, Zsolt; Kovalszky, Ilona; Molnár, Béla (2015)

BACKGROUND: Colorectal cancer (CRC) development is accompanied by changes in expression for several genes; but the details of the underlying regulatory procesess remain unknown. Our aims were to assess the role of epigenetic ...
Elsődleges genetikai vizsgálat Prader–Willi-szindróma igazolására

Ács, Orsolya Dóra; Péterfia, Bálint; Hollósi, Péter; Haltrich, Irén; Sallai, Ágnes; Luczay, Andrea; Buiting K; Horsthemke B; Török, Dóra; Szabó, András; Fekete, György (2018)

INTRODUCTION: According to the international literature, DNA methylation analysis of the promoter region of SNRPN locus is the most efficient way to start genetic investigation in patients with suspected Prader-Willi ...
Methylation Status of CYP27B1 and IGF2 Correlate to BMI SDS in Children with Obesity

Ács, Orsolya Dóra; Péterfia, Bálint; Hollósi, Péter; Luczay, Andrea; Török, Dóra; Szabó, András (2017)

OBJECTIVE: Worldwide increasing childhood obesity is due to interactions between environmental and genetic factors, linked together by epigenetic mechanisms such as DNA methylation. METHODS: 82 obese children (>95th BMI ...
Remodeling of extracellular matrix by normal and tumor-associated fibroblasts promotes cervical cancer progression

Fullár, Alexandra; József Dudás; Oláh, Lászlóné; Hollósi, Péter; Papp, Zoltán; Sobel, Gábor; Katalin Karászi; Paku, Sándor; Baghy, Kornélia; Kovalszky, Ilona (2015)

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