tallózása szerző szerint "SE/GYTK/GYHATAS/NAP-A-SE Új Antidepresszív Gyógyszercélpont Kutatócsoport"

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Acute and chronic escitalopram alter EEG gamma oscillations differently: relevance to therapeutic effects.

Papp Noémi; Vas Szilvia; Bogáthy Emese; Kátai Zita; Kostyalik Diána; Bagdy György (2018)

Brain oscillations in the gamma frequency band of the electroencephalogram (EEG) have been implicated in several sensory and cognitive processes, and have also been associated with numerous neuropsychiatric disorders, ...
A depresszió a poligénes vizsgálatok tükrében: a gének és a környezet közti kapcsolat szerepe

Gonda, Xénia (2018)
Alterations in the neuropeptide galanin system in major depressive disorder involve levels of transcripts, methylation, and peptide

Swapnali Barde; Joelle Rüegg; Josée Prud’homme; Tomas J Ekström; Palkovits Miklós; Gustavo Turecki; Bagdy György; Bagdy György; Robert Ihnatko; Elvar Theodorsson; Juhász Gabriella; Rochellys Diaz-Heijtz; Naguib Mechawar; Tomas G M Hökfelt (2016)

Major depressive disorder (MDD) is a substantial burden to patients, families, and society, but many patients cannot be treated adequately. Rodent experiments suggest that the neuropeptide galanin (GAL) and its three ...
A new stress sensor and risk factor for suicide: the T allele of the functional genetic variant in the GABRA6 gene

Gonda, Xénia; Sarginson J; Eszlári, Nóra; Petschner, Péter; Toth ZG; Baksa, Dániel; Hullam G; Anderson IM; Deakin JFW; Juhász, Gabriella; Bagdy, György (2017)

Low GABA transmission has been reported in suicide, and GABRA6 rs3219151 T allele has been associated with greater physiological and endocrine stress response in previous studies. Although environmental stress also plays ...
Association of ATP6V1B2 rs1106634 with lifetime risk of depression and hippocampal neurocognitive deficits: possible novel mechanisms in the etiopathology of depression

Gonda Xénia; Eszlári Nóra; Anderson IM; Deakin JF; Bagdy György; Juhász Gabriella (2016)

Current understanding and treatment of depression is limited to the monoaminergic theory with little knowledge of the involvement of other cellular processes. Genome-wide association studies, however, implicate several ...
Collaborative meta-analysis finds no evidence of a strong interaction between stress and 5-HTTLPR genotype contributing to the development of depression

RC Culverhouse; NL Saccone; AC Horton; Y Ma; KJ Anstey; T Banaschewski; M Burmeister; S Cohen-Woods; B Etain; HL Fisher; N Goldman; S Guillaume; J Horwood; Juhász Gabriella; KJ Lester; L Mandelli; CM Middeldorp; E Olié; S Villafuerte; TM Air; R Araya; L Bowes; R Burns; EM Byrne; C Coffey; WL Coventry; KAB Gawronski; D Glei; A Hatzimanolis; J-J Hottenga; I Jaussent; C Jawahar; C Jennen-Steinmetz; JR Kramer; M Lajnef; K Little; HM zu Schwabedissen; M Nauck; E Nederhof; Petschner Péter; WJ Peyrot; C Schwahn; G Sinnamon; D Stacey; Y Tian; C Toben; S Van der Auwera; N Wainwright; J-C Wang; G Willemsen; IM Anderson; V Arolt; C Åslund; Bagdy György; BT Baune; F Bellivier; DI Boomsma; P Courtet; U Dannlowski; EJC de Geus; JFW Deakin; S Easteal; T Eley; DM Fergusson; AM Goate; Gonda Xénia; HJ Grabe; C Holzman; EO Johnson; M Kennedy; M Laucht; NG Martin; MR Munafò; KW Nilsson; AJ Oldehinkel; CA Olsson; J Ormel; C Otte; GC Patton; BWJH Penninx; K Ritchie; M Sarchiapone; JM Scheid; A Serretti; JH Smit; NC Stefanis; PG Surtees; H Völzke; M Weinstein; M Whooley; JI Nurnberger Jr; N Breslau; LJ Bierut (2018)

The hypothesis that the S allele of the 5-HTTLPR serotonin transporter promoter region is associated with increased risk of depression, but only in individuals exposed to stressful situations, has generated much interest, ...
Depressive residual symptoms are associated with illness course characteristics in a sample of outpatients with bipolar disorder

Serafini G; Vazquez GH; Gonda, Xénia; Pompili M; Rihmer, Zoltán; Amore M (2018)

Rates of 50-70% of residual symptoms referring to subsyndromal manifestations between episodes that do not meet the required criteria for episode definition were reported in bipolar disorder (BD). However, the specific ...
Gene expression analysis indicates reduced memory and cognitive functions in the hippocampus and increase in synaptic reorganization in the frontal cortex 3 weeks after MDMA administration in Dark Agouti rats.

Petschner Péter; Tamási Viola; Ádori Csaba; Kirilly Eszter; Andó Rómeó; Tóthfalusi László; Bagdy György (2018)

BACKGROUND: 3,4-methylenedioxymethamphetamine (MDMA, "ecstasy") is a widely used entactogenic drug known to impair cognitive functions on the long-run. Both hippocampal and frontal cortical regions have well established ...
Genes Linking Mitochondrial Function, Cognitive Impairment and Depression are Associated with Endophenotypes Serving Precision Medicine

Petschner Péter; Gonda Xénia; Baksa Dániel; Eszlári Nóra; Michael Trivaks; Juhász Gabriella; Bagdy György (2018)

Mitochondria densely populate cells in central nervous system providing essential energy for neurons and influencing synaptic plasticity. Harm to these organelles can impair cognitive performance through damaged neurotransmission ...
Genome-wide association analysis reveals KCTD12 and miR-383-binding genes in the background of rumination

Eszlári, Nóra; Millinghoffer, András Dániel; Petschner, Péter; Gonda, Xénia; Baksa, Dániel; Pulay, Attila József; Réthelyi, János; Breen Gerome; Deakin John Francis William; Antal, Péter; Bagdy, György; Juhász, Gabriella (2019)

Ruminative response style is a passive and repetitive way of responding to stress, associated with several disorders. Although twin and candidate gene studies have proven the genetic underpinnings of rumination, no genome-wide ...
Krónikus szelektív szerotoninvisszavétel-gátló kezelés hatására bekövetkező transzkripciós változások: az állatkísérletek áttekintése

Kumar, Sahel; Gál, Zsófia; Gonda, Xénia; Huse, Robin J; Juhász, Gabriella; Bagdy, György; Petschner, Péter (2019)

The review focuses on transcriptomic changes following treatment with serotonin reuptake inhibitor (SSRI) antidepressants. We aimed to overview results of the most established methods for the investigation of the gene ...
Natural health products, dietary minerals and over-the-counter medications as add-on therapies to antidepressants in the treatment of major depressive disorder: a review

Döme, Péter; Tombor, László; Lazáry, Judit; Gonda, Xénia; Rihmer, Zoltan (2019)
Neurological soft signs significantly differentiate schizophrenia patients from healthy controls

Fountoulakis KN,; Panagiotidis P,; Gonda, Xénia; Kimiskidis V,; Nimatoudis I, (2018)

OBJECTIVE: Neurological soft signs (NSS) are a group of minor non-localisable neurological abnormalities found more often in patients with schizophrenia. The aim of the current study was to test for the effect of gender, ...
Possible predictors of age at illness onset and illness duration in a cohort study comparing younger adults and older major affective patients.

Serafini G; Gonda Xénia; Monacelli F; Pardini M; Pompili M; Rihmer Zoltán; Amore M (2018)

BACKGROUND: Major affective conditions are associated with significant disability and psychosocial impairment. Whether specific socio-demographic and clinical characteristics may distinguish subgroups of patients in terms ...
Prevalence and correlates of neurological soft signs in healthy controls without family history of any mental disorder: A neurodevelopmental variation rather than a specific risk factor?

Fountoulakis KN; Panagiotidis P; Kimiskidis V; Nimatoudis I; Gonda Xénia (2018)

OBJECTIVE: Neurological soft signs (NSS) are a group of minor non-localizable neurological abnormalities found more often in patients with schizophrenia and other mental disorders. The aim of the current study was to ...
Sensory profiles in unipolar and bipolar affective disorders: Possible predictors of response to antidepressant medications? A prospective follow-up study.

Engel-Yeger B; Bloch B; Gonda Xénia; Canepa G; Pompili M; Rihmer, Zoltán; Sher L; Rihmer Zoltán; Amore M; Serafini G (2018)

INTRODUCTION: Sensory processing patterns have been proposed as a stable dimension able to characterize individuals with major affective disorders, but to what extent specific impairments in sensory processing may be ...
Significance of risk polymorphisms for depression depends on stress exposure.

Gonda Xénia; Hullám Gábor István; Antal Péter; Eszlári Nóra; Petschner Péter; Hokfelt TG; Anderson IM; Deakin JFW; Juhász Gabriella; Bagdy György (2018)

Depression is a polygenic and multifactorial disorder where environmental effects exert a significant impact, yet most genetic studies do not consider the effect of stressors which may be one reason for the lack of replicable ...
Szorongás és depresszió – a vér-agy gát integritásának szerepe

Gál, Zsófia; Huse, Robin J; Gonda, Xénia; Kumar, Sahel; Juhász, Gabriella; Bagdy, György; Petschner, Péter (2019)

Among mental illnesses, anxiety disorders represent the second most frequent disorder. According to WHO Survey 2017, 264 million people suffer from their different types globally. The emergence of anxiety disorders can ...
Variants in the CNR1 gene predispose to headache with nausea in the presence of life stress.

Juhász, Gabriella; Csépány, Éva; Magyar, Máté; Édes, Andrea Edit; Eszlári, Nóra; Hullám, Gábor István; Antal P; Kökönyei, Gyöngyi; Anderson IM; Deakin JF; Bagdy, György (2017)

One of the main effects of the endocannabinoid system in the brain is stress adaptation with presynaptic endocannabinoid receptor 1 (CB1 receptors) playing a major role. In the present study, we investigated whether the ...
What's Love Got to do with it: Role of oxytocin in trauma, attachment and resilience..

Sharma, Samata R; Gonda, Xénia; Döme, Péter; Tarazi, Frank I (2020)

Oxytocin (OT) is a neurohypophysial hormone and neuropeptide produced by the hypothalamus and released by the pituitary gland. It has multiple physiological roles including stimulation of parturition and lactation, and ...

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tallózása szerző szerint "SE/GYTK/GYHATAS/NAP-A-SE Új Antidepresszív Gyógyszercélpont Kutatócsoport"

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