Introduction: Metals accumulate mainly in the kidney during cancer therapy with metal complexes. Since liver is the most important organ for chemical metabolism, its function can determine the effectiveness of therapy ...

Pigs are known to provide a sensitive model for studying complement (C) activation-related pseudoallergy (CARPA), a hypersensitivity reaction to liposomal and many other nanomedicines that limits their clinical use. The ...

INTRODUCTION: We and others demonstrated previously that preconditioning with endotoxin (LPS) protected from a subsequent lethal LPS challenge or from renal ischemia-reperfusion injury (IRI). LPS is effective in evoking ...