Show simple item record Steinberg S de Jong S Mattheisen M Costas J Demontis D Jamain S Pietilainen OP Lin K Papiol S Huttenlocher J Sigurdsson E Vassos E Giegling I Breuer R Fraser G Walker N Melle I Djurovic S Agartz I Tuulio-Henriksson A Suvisaari J Lonnqvist J Paunio T Olsen L Hansen T Ingason A Pirinen M Strengman E Hougaard DM Orntoft T Didriksen M Hollegaard MV Nordentoft M Abramova L Kaleda V Arrojo M Sanjuan J Arango C Etain B Bellivier F Meary A Schurhoff F Szoke A Ribolsi M Magni V Siracusano A Sperling S Rossner M Christiansen C Kiemeney LA Franke B van den Berg LH Veldink J Curran S Bolton P Poot M Staal W Rehnstrom K Kilpinen H Freitag CM Meyer J Magnusson P Saemundsen E Martsenkovsky I Bikshaieva I Martsenkovska I Vashchenko O Raleva M Paketchieva K Stefanovski B Durmishi N Pejovic Milovancevic M Lecic Tosevski D Silagadze T Naneishvili N Mikeladze N Surguladze S Vincent JB Farmer A Mitchell PB Wright A Schofield PR Fullerton JM Montgomery GW Martin NG Rubino IA van Winkel R Kenis G De Hert M Réthelyi, János Bitter, István Terenius L Jonsson EG Bakker S van Os J Jablensky A Leboyer M Bramon E Powell J Murray R Corvin A Gill M Morris D O'Neill FA Kendler K Riley B Craddock N Owen MJ O'Donovan MC Thorsteinsdottir U Kong A Ehrenreich H Carracedo A Golimbet V Andreassen OA Borglum AD Mors O Mortensen PB Werge T Ophoff RA Nothen MM Rietschel M Cichon S Ruggeri M Tosato S Palotie A St Clair D Rujescu D Collier DA Stefansson H Stefansson K 2015-03-10T12:56:51Z 2015-03-10T12:56:51Z 2014
dc.identifier 84891157599
dc.identifier.citation pagination=108-114; journalVolume=19; journalIssueNumber=1; journalTitle=MOLECULAR PSYCHIATRY;
dc.identifier.uri doi:10.1038/mp.2012.157
dc.description.abstract Epidemiological and genetic data support the notion that schizophrenia and bipolar disorder share genetic risk factors. In our previous genome-wide association study, meta-analysis and follow-up (totaling as many as 18 206 cases and 42 536 controls), we identified four loci showing genome-wide significant association with schizophrenia. Here we consider a mixed schizophrenia and bipolar disorder (psychosis) phenotype (addition of 7469 bipolar disorder cases, 1535 schizophrenia cases, 333 other psychosis cases, 808 unaffected family members and 46 160 controls). Combined analysis reveals a novel variant at 16p11.2 showing genome-wide significant association (rs4583255[T]; odds ratio=1.08; P=6.6 x 10(-11)). The new variant is located within a 593-kb region that substantially increases risk of psychosis when duplicated. In line with the association of the duplication with reduced body mass index (BMI), rs4583255[T] is also associated with lower BMI (P=0.0039 in the public GIANT consortium data set; P=0.00047 in 22 651 additional Icelanders).Molecular Psychiatry advance online publication, 20 November 2012; doi:10.1038/mp.2012.157.
dc.relation.ispartof urn:issn:1359-4184
dc.title Common variant at 16p11.2 conferring risk of psychosis
dc.type Journal Article 2015-01-23T11:18:24Z
dc.language.rfc3066 en
dc.identifier.mtmt 2134878
dc.identifier.wos 000328964700019
dc.identifier.pubmed 23164818
dc.contributor.department SE/AOK/K/Pszichiátriai és Pszichoterápiás Klinika
dc.contributor.institution Semmelweis Egyetem
dc.mtmt.swordnote CN GROUP CN Wellcome Trust Case Control Consortium 2

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