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Busulfan and melphalan versus carboplatin, etoposide, and melphalan as high-dose chemotherapy for high-risk neuroblastoma (HR-NBL1/SIOPEN): an international, randomised, multi-arm, open-label, phase 3 trial.

Ladenstein R; Potschger U; Pearson AD; Brock P; Luksch R; Castel V; Yaniv I; Papadakis V; Laureys G; Malis J; Balwierz W; Ruud E; Kogner P; Schroeder H; de Lacerda AF; Beck-Popovic M; Bician P; Garami, Miklós; Trahair T; Canete A; Ambros PF; Holmes K; Gaze M; Schreier G; Garaventa A; Vassal G; Michon J; Valteau-Couanet D; SIOP Europe Neuroblastoma Group (SIOPEN) (2017)

BACKGROUND: High-dose chemotherapy with haemopoietic stem-cell rescue improves event-free survival in patients with high-risk neuroblastoma; however, which regimen has the greatest patient benefit has not been established. ...
Immunohistochemical Ki67 after short-term hormone therapy identifies low-risk breast cancers as reliably as genomic markers.

Iwamoto T; Katagiri T; Niikura N; Miyoshi Y; Kochi M; Nogami T; Shien T; Motoki T; Taira N; Omori M; Tokuda Y; Fujiwara T; Doihara H; Győrffy, Balázs; Matsuoka J (2017)

BACKGROUND: The purpose of this study was to test whether immunohistochemical (IHC) Ki67 levels after short-term preoperative hormone therapy (post-Ki67) predict similar numbers of patients with favorable prognoses as ...
Estimation of the false-negative rate in newborn screening for congenital adrenal hyperplasia.

Votava F; Török, Dóra; Kovacs J; Moslinger D; Baumgartner-Parzer SM; Sólyom, János; Pribilincova Z; Battelino T; Lebl J; Frisch H; Waldhauser F; Middle European Society for Paediatric Endocrinology – Congenital Adrenal Hyperplasia (MESPE-CAH) Study Group (2005)

OBJECTIVE: Newborn screening based on measurement of 17alpha-hydroxyprogesterone (17-OHP) in a dried blood spot on filter paper is an effective tool for early diagnosis of congenital adrenal hyperplasia (CAH) due to ...
SHMT1 1420 and MTHFR 677 variants are associated with rectal but not colon cancer.

Komlósi, Lajos Viktor; Hitre, Erika; Pap E; Adleff V; Réti, Andrea; Székely, Éva; Biro A; Rudnai P; Schoket B; Müller, Judit; Tóth, Béla; Szabolcs, Ottó; Kásler, Miklós; Kralovánszky, Judit; Budai, Barna (2010)

BACKGROUND: Association between rectal or colon cancer risk and serine hydroxymethyltransferase 1 (SHMT1) C1420T or methylenetetrahydrofolate reductase (MTHFR) C677T polymorphisms was assessed. The serum total homocysteine ...
Gyermekkori vizelési zavarok és konzervatív terápiájuk

Bethlenfalvy-Perczel Zsófia; Kelen Kata; Szabó Attila (2017)

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