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dc.contributor.author Pál, Zsuzsanna
dc.contributor.author Tóthfalusi, László
dc.contributor.author Lőrincz, Zsolt
dc.contributor.author Gyorgy B
dc.contributor.author Molnár, Mária Judit
dc.contributor.author Falus, András
dc.contributor.author Buzás, Edit Irén
dc.date.accessioned 2015-02-04T11:59:35Z
dc.date.available 2015-02-04T11:59:35Z
dc.date.issued 2014
dc.identifier 84905780695
dc.identifier.citation pagination=224-228; journalVolume=276; journalIssueNumber=1-2; journalTitle=JOURNAL OF NEUROIMMUNOLOGY;
dc.identifier.uri http://repo.lib.semmelweis.hu//handle/123456789/1263
dc.identifier.uri doi:10.1016/j.jneuroim.2014.08.002
dc.description.abstract Increasing number of evidences support the role of glycosylation in the evolution of autoimmunity. We examined carbohydrate-reactive natural autoantibodies systematically for the first time in patients with autoimmune myasthenia gravis. Antibodies reactive to glycosaminoglycans were measured with CovaLink ELISA in the sera of 59 myasthenia patients as well as in 54 healthy controls. We used the GlycoChip carbohydrate array to characterize individual carbohydrate recognition patterns. Chondroitin-sulphate C and anti-alpha-mannose-specific IgG levels were significantly elevated in myasthenia patients. Unexpectedly, we found that immunosuppressants increased the levels of the protective IgM glycosaminoglycan-reactive natural antibodies demonstrating a new role for these agents in immunoregulation.
dc.relation.ispartof urn:issn:0165-5728
dc.title Immunosuppressants increase the levels of natural autoantibodies reactive with glycosaminoglycans in myasthenia gravis
dc.type Journal Article
dc.date.updated 2015-01-27T12:39:23Z
dc.language.rfc3066 en
dc.identifier.mtmt 2728740
dc.identifier.wos 000345490000031
dc.identifier.pubmed 25139014
dc.contributor.department SE/GYTK/Gyógyszerhatástani Intézet
dc.contributor.department SE/AOK/K/Neurológiai Klinika
dc.contributor.department SE/AOK/I/Genomikai Medicina és Ritka Betegségek Intézete
dc.contributor.department SE/AOK/I/Genetikai, Sejt- és Immunbiológiai Intézet
dc.contributor.institution Semmelweis Egyetem


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