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dc.contributor.author Pár Alajos
dc.contributor.author Pár Gabriella
dc.contributor.author Tornai István
dc.contributor.author Szalay Ferenc
dc.contributor.author Varszegi D
dc.contributor.author Frater E
dc.contributor.author Papp Mária
dc.contributor.author Lengyel Gabriella
dc.contributor.author Fehér J
dc.contributor.author Varga M
dc.contributor.author Gervain J
dc.contributor.author Schuller J
dc.contributor.author Nemes Zsuzsanna
dc.contributor.author Péterfi Zoltán
dc.contributor.author Tusnadi A
dc.contributor.author Hunyady Béla
dc.contributor.author Haragh A
dc.contributor.author Szinku Zs
dc.contributor.author Vincze Áron
dc.contributor.author Szereday László
dc.contributor.author Kisfali Péter
dc.contributor.author Melegh Béla
dc.date.accessioned 2014-05-07T12:53:19Z
dc.date.available 2014-05-07T12:53:19Z
dc.date.issued 2014
dc.identifier.issn 1756-0500
dc.identifier.uri http://repo.lib.semmelweis.hu//handle/123456789/126
dc.identifier.uri doi:10.1186/1756-0500-7-12
dc.description.abstract BACKGROUND: Previous studies have shown that single nucleotide polymorphisms (SNP) in IL28B and IL10R are associated with sustained virological response (SVR) in chronic hepatitis C patients treated with pegilated interferon plus ribavirin (P/R). The present study extends our earlier investigations on a large East-Central European cohort. The allele frequencies of IL28B and IL10R in genotype 1 HCV infection were compared with that of healthy controls for the purpose of examining the relationship between the polymorphisms and the SVR to P/R treatment. METHODS: A total of 748 chronic HCV1 infected patients (365 male, 383 female; 18-82 years) and 105 voluntary blood donors as controls were enrolled. Four hundred and twenty HCV patients were treated with P/R for 24-72 weeks, out of them 195 (46.4%) achieved SVR. The IL28 rs12979860 SNP was determined using Custom Taqman SNP Genotyping Assays. The IL10R -1087 (also known as IL10R -1082 (rs1800896) promoter region SNP was determined by RT-PCR and restriction fragment length polymorphism analysis. RESULTS: The IL28B CC genotype occurred with lower frequency in HCV patients than in controls (26.1% vs 51.4%, p<0.001). P/R treated patients with the IL28B CC genotype achieved higher SVR rate, as compared to patients with CT (58.6% vs 40.8%, p=0.002). The prevalence of IL10R -1087 GG genotype was lower in patients than in controls (31.8 % vs 52.2%, p<0.001). Among patients achieving SVR, the IL10R -1087 GG genotype occurred with higher frequency than the AA (32.0% vs 17.4%, p=0.013). The IL28B T allele plus IL10R A allele combination was found with higher prevalence in patients than in controls (52% vs 20.7%, p<0.001). The IL28B CC plus IL10R A allele combination occurred with higher frequency among patients with SVR than in non-responders (21.3% vs 12.8%, p=0.026). Both the IL28B CC plus IL10R GG and the IL28B CC plus IL10R A allele combinations occurred with lower frequency in patients than in controls. CONCLUSIONS: In our HCV1 patients, both the IL28B CC and IL10R GG genotypes are associated with clearance of HCV. Moreover, distinct IL28B and IL10R allele combinations appear to be protective against chronic HCV1 infection and predictors of response to P/R therapy. hu
dc.relation.ispartof urn:issn:1756-0500
dc.subject Genetic polymorphism hu
dc.subject Hepatitis C virus hu
dc.subject Interferon hu
dc.subject Interleukin-28B hu
dc.subject Interleukin-10 hu
dc.title IL28B and IL10R -1087 polymorphisms are protective for chronic genotype 1 HCV infection and predictors of response to interferon-based therapy in an East-Central European cohort. hu
dc.type Journal Article hu
dc.date.updated 2014-05-07T12:42:53Z
dc.language.rfc3066 en hu
dc.identifier.mtmt 2495110
dc.identifier.pubmed 24398031
dc.contributor.department Pécsi Tudományegyetem
dc.contributor.institution Pécsi Tudományegyetem


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