dc.contributor.author |
Heinzlmann, Andrea |
|
dc.contributor.author |
Tóth, Zsuzsanna |
|
dc.contributor.author |
Köves, Katalin |
|
dc.date.accessioned |
2016-10-13T06:54:20Z |
|
dc.date.available |
2016-10-13T06:54:20Z |
|
dc.date.issued |
2011 |
|
dc.identifier |
79951579774 |
|
dc.identifier.citation |
pagination=101-108;
journalVolume=43;
journalIssueNumber=1;
journalTitle=JOURNAL OF MOLECULAR NEUROSCIENCE; |
|
dc.identifier.uri |
http://repo.lib.semmelweis.hu//handle/123456789/1289 |
|
dc.identifier.uri |
doi:10.1007/s12031-010-9395-0 |
|
dc.description.abstract |
The primary sensory neurons use glutamate as a major
neurotransmitter. Several neuropeptides are also found in these
neurons. In our laboratory we demonstrated secretin-like
immunoreactivity in primary sensory neurons of several species
including human, rat and cat. In the present experiment
utilizing in situ hybridization, we have demonstrated for the
first time that secretin is not only immunostained but is also
expressed in the primary sensory neurons of the trigeminal
ganglion of male rats. In intact rats, secretin mRNA was not
observed; we had to use intracerebroventricular colchicine
administration to induce the expression of secretin. Secretin
was expressed in about 5% of the cells in all the three
subdivisions of the trigeminal ganglion. The secretin-
synthetizing cells were large and medium sized, and their mean
diameter was about 50 mum. When we compared the percentage and
the size of secretin to that of calcitonin gene-related peptide
(CGRP), substance-P (SP) and vasoactive intestinal polypeptide
(VIP) cells, it was found that CGRP, SP and VIP are present in
about 15-20% of the cells and their mean diameter is about 20-
25 mum. The morphometric data indicate that secretin is present
in a subdivision of neurons that is different from the
subdivision of the CGRP, SP and VIP cells. It is suggested that
secretin may modulate the function of the primary
neurotransmitter. |
|
dc.relation.ispartof |
urn:issn:0895-8696 |
|
dc.title |
Secretin mRNA in the subdivision of primary sensory neurons in the trigeminal ganglion of rats. |
|
dc.type |
Journal Article |
|
dc.date.updated |
2015-02-02T11:54:03Z |
|
dc.language.rfc3066 |
en |
|
dc.identifier.mtmt |
1460954 |
|
dc.identifier.wos |
000286106100015 |
|
dc.identifier.pubmed |
20582488 |
|
dc.contributor.department |
MTA TKI/MTA-SE Neuromorfológiai és Neuroendokrin Kutatócsoport (2006-ig: MTA-SE Neuroendokrin Kutatócsoport) |
|
dc.contributor.department |
SE/AOK/I/Anatómiai, Szövet- és Fejlődéstani Intézet |
|
dc.contributor.department |
SE/AOK/I/Humánmorfológiai és Fejlődésbiológiai Intézet |
|
dc.contributor.institution |
MTA Támogatott Kutatócsoportok |
|
dc.contributor.institution |
Semmelweis Egyetem |
|