dc.contributor.author | Szijártó István András | |
dc.contributor.author | Molnár Gergő Attila | |
dc.contributor.author | Mikolás Esztella Zsóka | |
dc.contributor.author | Fisi Viktória | |
dc.contributor.author | Cseh Judit | |
dc.contributor.author | Laczy Boglárka | |
dc.contributor.author | Kovács Tibor | |
dc.contributor.author | Böddi Katalin | |
dc.contributor.author | Takátsy Anikó | |
dc.contributor.author | Maik Gollasch | |
dc.contributor.author | Koller Ákos | |
dc.contributor.author | Wittmann István | |
dc.date.accessioned | 2015-02-04T08:29:14Z | |
dc.date.available | 2015-02-04T08:29:14Z | |
dc.date.issued | 2014 | |
dc.identifier.citation | pagination=749-752;journalVolume=46;journalIssueNumber=11;journalTitle=HORMONE AND METABOLIC RESEARCH; | hu |
dc.identifier.uri | http://repo.lib.semmelweis.hu//handle/123456789/1317 | |
dc.identifier.uri | doi:10.1055/s-0034-1387701 | |
dc.description.abstract | Previous studies have shown that in diabetes mellitus, insulin-induced relaxation of arteries is impaired and the level of ortho-tyrosine (o-Tyr), an oxidized amino acid is increased. Thus, we hypothesized that elevated vascular level of o-Tyr contributes to the impairment of insulin-induced vascular relaxation. Rats were fed with o-Tyr for 4 weeks. Insulin-induced vasomotor responses of isolated femoral artery were studied using wire myography. Vascular o-Tyr content was measured by HPLC, whereas immunoblot analyses were preformed to detect eNOS phosphorylation. Sustained oral supplementation of rats with o-Tyr increased the content of o-Tyr in the arterial wall and significantly reduced the relaxations to insulin. Sustained supplementation of cultured endothelial cells with o-Tyr increased the incorporation of o-Tyr and mitigated eNOS Ser (1 177) phosphorylation to insulin. Increasing arterial wall o-Tyr level attenuates insulin-induced relaxation - at least in part - by decreasing eNOS activation. Elevated level of o-Tyr could be an underlying mechanism for vasomotor dysfunction in diabetes mellitus. | hu |
dc.relation.ispartof | urn:issn:0018-5043 | |
dc.title | Elevated Vascular Level of ortho-Tyrosine Contributes to the Impairment of Insulin-Induced Arterial Relaxation. | hu |
dc.type | Journal Article | hu |
dc.date.updated | 2015-02-04T08:26:49Z | |
dc.language.rfc3066 | en | hu |
dc.identifier.mtmt | 2743437 | |
dc.identifier.wos | 000343583200001 | |
dc.identifier.pubmed | 25208272 | |
dc.contributor.department | PTE/Szentágothai János Kutatóközpont | |
dc.contributor.department | SE/AOK/I/Kórélettani Intézet | |
dc.contributor.institution | Pécsi Tudományegyetem | |
dc.contributor.institution | Semmelweis Egyetem |